A5039020483- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
- T-cell and B-cell Immunology
- Ocular Infections and Treatments
- Inflammasome and immune disorders
- Pulmonary Hypertension Research and Treatments
- Immune Cell Function and Interaction
- Hereditary Neurological Disorders
- Morinda citrifolia extract uses
- Cytokine Signaling Pathways and Interactions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bone Metabolism and Diseases
- Myasthenia Gravis and Thymoma
- Rheumatoid Arthritis Research and Therapies
- Corneal Surgery and Treatments
- Salivary Gland Disorders and Functions
- Peripheral Neuropathies and Disorders
- Cell death mechanisms and regulation
- Cardiac Fibrosis and Remodeling
- Ocular Surface and Contact Lens
Lanzhou University Second Hospital
2024
Lanzhou University
2024
Biogen (United States)
2009-2015
Howard Hughes Medical Institute
2000
Vertex Pharmaceuticals (United States)
2000
Yale University
2000
The number of neurons in the mammalian brain is determined by a balance between cell proliferation and programmed death. Recent studies indicated that Bcl-X L prevents, whereas Caspase-3 mediates, death developing nervous system, but whether directly blocks apoptotic function vivo not known. To examine this question, we generated bcl-x / caspase-3 double mutants found deficiency abrogated increased apoptosis postmitotic hematopoietic embryonic lethality caused mutation. In contrast, ,...
To investigate the expression of tumour necrosis factor (TNF)-like weak inducer apoptosis (TWEAK) and its receptor fibroblast growth inducible 14 (Fn14) in inflamed synovium patients with arthritis, as TWEAK blockade has been observed to have a beneficial effect an animal model rheumatoid arthritis (RA).Synovial tissue (ST) biopsies were obtained from 6 early, methotrexate-naive RA well 13 16 psoriatic (PsA) who matched for treatment disease duration. Serial ST samples separate cohort before...
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated neuropathy. While CIDP typically affects the peripheral nerves in limbs, involvement of cranial atypical, and cases muscle atrophy secondary to nerve are exceptionally rare. A 30-year-old female patient, who complained numbness weakness her was diagnosed with after experiencing tongue sternocleidomastoid muscles, along fibrillation during a neurological examination. Additionally, patient had hypothyroidism caused...
<h3>Background</h3> The cellular characterization of the immune infiltrate in exocrine glands from patients with primary Sjögren9s syndrome (pSS) has relied so far on methods low dimensionality. As a result, our knowledge events taking place these is limited. <h3>Objectives</h3> In order to quantify variations associated pathogenesis, we used here highly multiparametric cytometry by time-of-flight (CyTOF) analyze diagnostic biopsies pSS and non-pSS sicca controls. <h3>Methods</h3> CyTOF...