A5093643833- Cutaneous lymphoproliferative disorders research
- CAR-T cell therapy research
- Fungal Infections and Studies
- Lymphoma Diagnosis and Treatment
- Melanoma and MAPK Pathways
Aarhus University Hospital
2024-2025
Aarhus University
2025
Patients with Sézary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma (CTCL), are prone to Staphylococcus aureus infections and have poor prognosis due treatment resistance. Here, we report that S staphylococcal enterotoxins (SE) induce drug resistance in malignant T cells against therapeutics commonly used CTCL. Supernatant from patient-derived, SE-producing recombinant SE significantly inhibit cell death induced by histone deacetylase (HDAC) inhibitor romidepsin primary...
Cutaneous T-cell lymphomas are a heterogeneous group of non-Hodgkin lymphomas. Early stages often controlled with skin-directed therapy, such as topical corticosteroids, chlormethine gel, or UV whereas advanced warrant more aggressive approach systemic antibody targeted therapy including mogamulizumab, brentuximab vedotin, alemtuzumab. A retrospective cohort case series 27 patients from Aarhus University Hospital, Denmark is presented, evaluating real-world outcomes cutaneous treated...