A5102875742- Plant Stress Responses and Tolerance
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Mechanisms of cancer metastasis
- Microtubule and mitosis dynamics
- DNA Repair Mechanisms
University of Colorado Boulder
2016
Targeting mitotic kinase monopolar spindle 1 (Mps1) for tumor therapy has been investigated many years. Although it was suggested that Mps1 regulates cell viability through its role in assembly checkpoint (SAC), the underlying mechanism remains less defined. In an endeavor to reveal of high levels development colon cancer, we unexpectedly found amount required survival far exceeds maintaining SAC aneuploid lines. This suggests other functions besides are also employed maintain viability....
Summary Brassinosteroids (BRs) are plant hormones that essential in growth and development. BRASSINOSTEROID‐INSENSITIVE 1 (BRI1) BRI1 ASSOCIATED RECEPTOR KINASE (BAK1), which located on the plasma membrane, function as co‐receptors accept transmit BR signals. PROHIBITIN 3 (PHB3) was identified both BAK1 complexes by affinity purification LC‐MS/MS analysis. Biochemical data showed BRI1/BAK1 interacted with PHB3 vitro vivo . phosphorylated When Thr‐80 amino acid mutated to Ala, mutant protein...