A5038569446- Acute Lymphoblastic Leukemia research
- Genomics and Chromatin Dynamics
- Chronic Myeloid Leukemia Treatments
- RNA modifications and cancer
- CAR-T cell therapy research
- Genomic variations and chromosomal abnormalities
- T-cell and Retrovirus Studies
- Childhood Cancer Survivors' Quality of Life
- Lymphoma Diagnosis and Treatment
- RNA Research and Splicing
- Acute Myeloid Leukemia Research
University College London
2022-2024
London Cancer
2024
CRUK Lung Cancer Centre of Excellence
2023-2024
Failure to respond induction chemotherapy portends a poor outcome in childhood acute lymphoblastic leukemia (ALL) and is more frequent T-cell ALL (T-ALL) than B-cell ALL. We aimed address the limited understanding of clinical genetic factors that influence cohort patients with T-ALL failure (IF).
Oncogenes can be activated in cis through multiple mechanisms including enhancer hijacking events and noncoding mutations that create enhancers or promoters de novo . These paradigms have helped parse somatic variation of cancer genomes, thereby providing a rationale to identify noncanonical gene activation. Here we describe novel mechanism oncogene activation whereby focal copy number loss an intronic element within the FTO leads aberrant expression IRX3 , T cell acute lymphoblastic...