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Alexander Abreo

ORCID: 0009-0006-5615-5345
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A5009331967
Research Areas
  • Immune cells in cancer
  • Chemokine receptors and signaling
  • Acute Myeloid Leukemia Research
  • Inflammation biomarkers and pathways
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Cancer-related molecular mechanisms research
  • RNA modifications and cancer
  • Immunodeficiency and Autoimmune Disorders
  • RNA regulation and disease
  • Blood disorders and treatments
  • Immune Cell Function and Interaction
  • Congenital Diaphragmatic Hernia Studies

The Ohio State University
 2023

University of New Orleans
 2020

 Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase
OPENALEX - Publications 
Himanshu Savardekar Carter Allen Hyeongseon Jeon Jianying Li Dionisia Quiroga and 14 more Emily Schwarz Richard C. Wu Sara Zelinskas Gabriella Lapurga Alexander Abreo Andrew Stiff Jami Shaffer Bradley W. Blaser Matthew Old Robert Wesolowski Gang Xin Kari Kendra Dongjun Chung William E. Carson

Abstract Myeloid-derived suppressor cell (MDSC) levels are elevated in patients with cancer and contribute to reduced efficacy of immune checkpoint therapy. MDSC express Bruton's tyrosine kinase (BTK) BTK inhibition ibrutinib, an FDA-approved irreversible inhibitor BTK, leads expansion/function mice significantly improves the antitumor activity anti-PD-1 antibody treatments. Single-cell RNA sequencing (scRNA-seq) was used characterize effect ibrutinib on gene expression...

10.1158/1541-7786.mcr-22-0572 article EN Molecular Cancer Research 2023-11-28
 Supplementary Figure 3 from Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase
OPENALEX - Publications 
Himanshu Savardekar Carter Allen Hyeongseon Jeon Jianying Li Dionisia Quiroga and 14 more Emily Schwarz Richard C. Wu Sara Zelinskas Gabriella Lapurga Alexander Abreo Andrew Stiff Jami Shaffer Bradley W. Blaser Matthew Old Robert Wesolowski Gang Xin Kari Kendra Dongjun Chung William E. Carson

<p>Comparison of melanoma MDSC to breast (A-B) and head neck (C-D).</p>

10.1158/1541-7786.25325119.v1 preprint EN cc-by 2024-03-01
 Supplementary Figure 4 from Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase
OPENALEX - Publications 
Himanshu Savardekar Carter Allen Hyeongseon Jeon Jianying Li Dionisia Quiroga and 14 more Emily Schwarz Richard C. Wu Sara Zelinskas Gabriella Lapurga Alexander Abreo Andrew Stiff Jami Shaffer Bradley W. Blaser Matthew Old Robert Wesolowski Gang Xin Kari Kendra Dongjun Chung William E. Carson

<p>Individual UMAP plots melanoma MDSC treated with DMSO control or 5 µM ibrutinib for 4h.</p>

10.1158/1541-7786.25325116 preprint EN cc-by 2024-03-01
 Data from Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase
OPENALEX - Publications 
Himanshu Savardekar Carter Allen Hyeongseon Jeon Jianying Li Dionisia Quiroga and 14 more Emily Schwarz Richard C. Wu Sara Zelinskas Gabriella Lapurga Alexander Abreo Andrew Stiff Jami Shaffer Bradley W. Blaser Matthew Old Robert Wesolowski Gang Xin Kari Kendra Dongjun Chung William E. Carson

<div>Abstract<p>Myeloid-derived suppressor cell (MDSC) levels are elevated in patients with cancer and contribute to reduced efficacy of immune checkpoint therapy. MDSC express Bruton's tyrosine kinase (BTK) BTK inhibition ibrutinib, an FDA-approved irreversible inhibitor BTK, leads expansion/function mice significantly improves the antitumor activity anti-PD-1 antibody treatments. Single-cell RNA sequencing (scRNA-seq) was used characterize effect ibrutinib on gene expression...

10.1158/1541-7786.c.7100173.v1 preprint EN 2024-03-01
 Supplementary Figure 8 from Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase
OPENALEX - Publications 
Himanshu Savardekar Carter Allen Hyeongseon Jeon Jianying Li Dionisia Quiroga and 14 more Emily Schwarz Richard C. Wu Sara Zelinskas Gabriella Lapurga Alexander Abreo Andrew Stiff Jami Shaffer Bradley W. Blaser Matthew Old Robert Wesolowski Gang Xin Kari Kendra Dongjun Chung William E. Carson

<p>FACS purified MDSC viability after 24h DMSO or ibrutinib treatment.</p>

10.1158/1541-7786.25325104 preprint EN cc-by 2024-03-01
 Supplementary Figure 6 from Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase
OPENALEX - Publications 
Himanshu Savardekar Carter Allen Hyeongseon Jeon Jianying Li Dionisia Quiroga and 14 more Emily Schwarz Richard C. Wu Sara Zelinskas Gabriella Lapurga Alexander Abreo Andrew Stiff Jami Shaffer Bradley W. Blaser Matthew Old Robert Wesolowski Gang Xin Kari Kendra Dongjun Chung William E. Carson

<p>Expression thresholds for CD14 gene expression.</p>

10.1158/1541-7786.25325110 preprint EN cc-by 2024-03-01
 Supplementary Figure 1 from Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase
OPENALEX - Publications 
Himanshu Savardekar Carter Allen Hyeongseon Jeon Jianying Li Dionisia Quiroga and 14 more Emily Schwarz Richard C. Wu Sara Zelinskas Gabriella Lapurga Alexander Abreo Andrew Stiff Jami Shaffer Bradley W. Blaser Matthew Old Robert Wesolowski Gang Xin Kari Kendra Dongjun Chung William E. Carson

<p>MDSC isolation via FACS.</p>

10.1158/1541-7786.25325125 preprint NL cc-by 2024-03-01
 Supplementary Figure 5 from Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase
OPENALEX - Publications 
Himanshu Savardekar Carter Allen Hyeongseon Jeon Jianying Li Dionisia Quiroga and 14 more Emily Schwarz Richard C. Wu Sara Zelinskas Gabriella Lapurga Alexander Abreo Andrew Stiff Jami Shaffer Bradley W. Blaser Matthew Old Robert Wesolowski Gang Xin Kari Kendra Dongjun Chung William E. Carson

<p>Pathway analysis results from IPA of melanoma MDSC treated with DMSO control or 4h ibrutinib.</p>

10.1158/1541-7786.25325113.v1 preprint EN cc-by 2024-03-01
 Supplementary Figure 7 from Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase
OPENALEX - Publications 
Himanshu Savardekar Carter Allen Hyeongseon Jeon Jianying Li Dionisia Quiroga and 14 more Emily Schwarz Richard C. Wu Sara Zelinskas Gabriella Lapurga Alexander Abreo Andrew Stiff Jami Shaffer Bradley W. Blaser Matthew Old Robert Wesolowski Gang Xin Kari Kendra Dongjun Chung William E. Carson

<p>Analysis of subsets (PMN-MDSC DE vs. double positive MDSC).</p>

10.1158/1541-7786.25325107 preprint EN cc-by 2024-03-01
 Supplementary Figure 5 from Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase
OPENALEX - Publications 
Himanshu Savardekar Carter Allen Hyeongseon Jeon Jianying Li Dionisia Quiroga and 14 more Emily Schwarz Richard C. Wu Sara Zelinskas Gabriella Lapurga Alexander Abreo Andrew Stiff Jami Shaffer Bradley W. Blaser Matthew Old Robert Wesolowski Gang Xin Kari Kendra Dongjun Chung William E. Carson

<p>Pathway analysis results from IPA of melanoma MDSC treated with DMSO control or 4h ibrutinib.</p>

10.1158/1541-7786.25325113 preprint EN cc-by 2024-03-01
 Supplementary Figure 1 from Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase
OPENALEX - Publications 
Himanshu Savardekar Carter Allen Hyeongseon Jeon Jianying Li Dionisia Quiroga and 14 more Emily Schwarz Richard C. Wu Sara Zelinskas Gabriella Lapurga Alexander Abreo Andrew Stiff Jami Shaffer Bradley W. Blaser Matthew Old Robert Wesolowski Gang Xin Kari Kendra Dongjun Chung William E. Carson

<p>MDSC isolation via FACS.</p>

10.1158/1541-7786.25325125.v1 preprint NL cc-by 2024-03-01
 Supplementary Figure 6 from Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase
OPENALEX - Publications 
Himanshu Savardekar Carter Allen Hyeongseon Jeon Jianying Li Dionisia Quiroga and 14 more Emily Schwarz Richard C. Wu Sara Zelinskas Gabriella Lapurga Alexander Abreo Andrew Stiff Jami Shaffer Bradley W. Blaser Matthew Old Robert Wesolowski Gang Xin Kari Kendra Dongjun Chung William E. Carson

<p>Expression thresholds for CD14 gene expression.</p>

10.1158/1541-7786.25325110.v1 preprint EN cc-by 2024-03-01
 Supplementary Figure 7 from Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase
OPENALEX - Publications 
Himanshu Savardekar Carter Allen Hyeongseon Jeon Jianying Li Dionisia Quiroga and 14 more Emily Schwarz Richard C. Wu Sara Zelinskas Gabriella Lapurga Alexander Abreo Andrew Stiff Jami Shaffer Bradley W. Blaser Matthew Old Robert Wesolowski Gang Xin Kari Kendra Dongjun Chung William E. Carson

<p>Analysis of subsets (PMN-MDSC DE vs. double positive MDSC).</p>

10.1158/1541-7786.25325107.v1 preprint EN cc-by 2024-03-01
 Supplementary Figure 8 from Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase
OPENALEX - Publications 
Himanshu Savardekar Carter Allen Hyeongseon Jeon Jianying Li Dionisia Quiroga and 14 more Emily Schwarz Richard C. Wu Sara Zelinskas Gabriella Lapurga Alexander Abreo Andrew Stiff Jami Shaffer Bradley W. Blaser Matthew Old Robert Wesolowski Gang Xin Kari Kendra Dongjun Chung William E. Carson

<p>FACS purified MDSC viability after 24h DMSO or ibrutinib treatment.</p>

10.1158/1541-7786.25325104.v1 preprint EN cc-by 2024-03-01
 Supplementary Figure 3 from Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase
OPENALEX - Publications 
Himanshu Savardekar Carter Allen Hyeongseon Jeon Jianying Li Dionisia Quiroga and 14 more Emily Schwarz Richard C. Wu Sara Zelinskas Gabriella Lapurga Alexander Abreo Andrew Stiff Jami Shaffer Bradley W. Blaser Matthew Old Robert Wesolowski Gang Xin Kari Kendra Dongjun Chung William E. Carson

<p>Comparison of melanoma MDSC to breast (A-B) and head neck (C-D).</p>

10.1158/1541-7786.25325119 preprint EN cc-by 2024-03-01
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