A5010292078- Trace Elements in Health
- Iron Metabolism and Disorders
- Cardiac Health and Mental Health
- Parkinson's Disease Mechanisms and Treatments
- Corrosion Behavior and Inhibition
- Neurological disorders and treatments
- Heavy Metal Exposure and Toxicity
- Adenosine and Purinergic Signaling
- Cardiovascular and exercise physiology
- Heart Failure Treatment and Management
Defense Health Agency
2024
United States Army
2024
Capital University
2024
California State University, Fullerton
2014-2018
Ceruloplasmin, the main copper binding protein in blood plasma, has been of particular interest for its role efflux iron from cells, but additional functions. Here we tested hypothesis that it releases cell uptake by interacting with a surface reductase and transporters, producing apoceruloplasmin. Uptake transepithelial transport ceruloplasmin was demonstrated mammary epithelial monolayers (PMC42) tight junctions grown bicameral chambers, purified human 64Cu-labeled secreted HepG2 cells....
National Capital Consortium Family Medicine Residency, Fort Belvoir, VA The corresponding author is Aaron P. Montgomery; [email protected] authors declare no conflicts of interest. opinions and assertions contained herein are those the not to be construed as official or reflecting views U.S. Navy Medical Department, at large, Army Defense Health Agency, Department Defense.
The main Cu‐binding protein of blood plasma, ceruloplasmin (Cp), has mainly been studied for its role in mediating cellular iron efflux but also other functions, and as shown by i.v. infusion 67 Cu‐Cp, Cu enters most major organs. To determine whether it delivers directly to cells the mechanisms involved, we incubated purified radio‐copper‐labeled unlabeled Cp with measured rates uptake accumulation. Uptake was demonstrated human mammary epithelial cell monolayers (PMC42 cells) tight...