A5100786751- Mitochondrial Function and Pathology
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Metabolism and Genetic Disorders
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Systemic Lupus Erythematosus Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- Congenital Heart Disease Studies
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Cerebral Venous Sinus Thrombosis
- Breast Cancer Treatment Studies
- Stroke Rehabilitation and Recovery
- Advanced MRI Techniques and Applications
- Gastrointestinal Tumor Research and Treatment
- MRI in cancer diagnosis
- Cancer-related molecular mechanisms research
- Cardiac Ischemia and Reperfusion
- Venous Thromboembolism Diagnosis and Management
- Peptidase Inhibition and Analysis
- Folate and B Vitamins Research
Xuzhou Central Hospital
2018-2025
National Clinical Research Center for Digestive Diseases
2018-2025
Capital Medical University
2009-2025
Beijing Tian Tan Hospital
2018-2025
Fudan University Shanghai Cancer Center
2014-2025
Sichuan University
2025
Army Medical University
2025
Chongqing Medical University
2020-2025
Second Affiliated Hospital of Chongqing Medical University
2025
Dalian Medical University
2025
The 2013-15 Ebola virus disease epidemic in west Africa greatly accelerated the development of vaccine. We aimed to analyse immune persistence induced by one shot an adenovirus type-5 vector-based vaccine up 6 months and effect boosting with a homologous vector healthy adults China.In randomised, double-blind, placebo-controlled, phase 1 clinical trial site Jiangsu Province, China, 120 aged 18-60 years received initial dose intramuscular 4·0 × 1010 viral particles, 1·6 1011 or placebo, were...
Mitochondrial respiratory chain (RC) disease therapies directed at intra-mitochondrial pathology are largely ineffective. Recognizing that RC dysfunction invokes pronounced extra-mitochondrial transcriptional adaptations, particularly involving dysregulated translation, we hypothesized translational dysregulation is itself contributing to the pathophysiology of disease. Here, investigated activities, and effects from direct inhibition, a central regulator (mTORC1) its downstream biological...
To understand the roles of microRNAs (miRNAs) in proliferative lupus nephritis (LN).A high-throughput analysis miRNA pattern kidneys LN patients and controls was performed by molecular digital detection. Urinary miRNAs were measured quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Target gene expression human mesangial cells evaluated arrays qRT-PCR. Human epidermal growth factor receptor 2 (HER-2) analyzed immunohistochemistry kidney samples from a murine model lupus....
Abstract Infantile cholestatic disorders arise in the context of progressively developing intrahepatic bile ducts. Biliary atresia (BA), a progressive fibroinflammatory disorder extra- and ducts, is most common identifiable cause infantile cholestasis leading indication for liver transplantation children. The etiology BA unclear, although there some evidence viral, toxic, complex genetic causes, exclusive occurrence during period biliary growth remodeling suggests an importance developmental...
Primary mitochondrial respiratory chain (RC) diseases are heterogeneous in etiology and manifestations but collectively impair cellular energy metabolism. Mechanism(s) by which RC dysfunction causes global sequelae poorly understood. To identify a common response to disease, integrated gene, pathway, systems biology analyses were performed human primary disease skeletal muscle fibroblast transcriptomes. Significant changes evident across diverse complex genetic etiologies that consistent...
Objective: Inflammation plays a key role in the etiology and pathology of postoperative cognitive dysfunction (POCD). Cyclooxygenase (COX)-2 inhibitor celecoxib is used for treatment acute pain due to its potent anti-inflammatory analgesic effects. Herein, we evaluated effects on POCD geriatric patients. Methods: A total 178 patients undergoing knee arthroplasty were randomly divided into two groups treated with (group C) or placebo P). The levels perioperative plasma COX-2, IL-1β, IL-6,...
Background To investigate whether collateral status could modify the associations between post-thrombectomy blood pressure (BP) measures and outcomes. Methods Results Patients with anterior-circulation large-vessel-occlusion successfully recanalized in a multicenter endovascular thrombectomy registry were enrolled. Pretreatment was graded dichotomized (good/poor) angiography. Maximum, minimum, mean systolic BP (SBP) variability (assessed by SD, coefficient of variation) during initial 24...
333 Background: Docetaxel has demonstrated promising activity in gastric cancer, both as monotherapy and combination with other agents. Albumin-bound docetaxel (HB1801) is a new kind of taxane many advantages compared docetaxel. Previous phase I study that HB1801 showed preliminary efficacy patients cancer. Methods: In this II study, eligible were aged 18-75 years histologically confirmed or gastroesophageal junction (G/GEJ) adenocarcinoma, who progressed on at least first line combined...
ABSTRACT Background Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) can radiographically mimic multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). The hallmarks cortical lesion, central vein sign (CVS) paramagnetic rim lesions identified in MS have not yet been comprehensively investigated MOGAD. Methods We characterized 45 patients with MOGAD using 7.0 Tesla (7 T) MRI at two academic research hospitals China Germany. 7 T MRI, laboratory,...
Background: Kearns-Sayre syndrome (KSS) is a mitochondrial DNA (mtDNA) deletion disorder characterized by triad of onset before 20 years age, ophthalmoplegia, and pigmentary retinopathy. The heart central nervous system are commonly involved. We summarized clinical brain magnetic resonance imaging (MRI) features cohort Chinese KSS patients. Methods: Nineteen patients confirmed muscle biopsy mtDNA analysis were enrolled. examined profiles, mainly focusing on changes in electrocardiogram (ECG)...
Deep vein thrombosis (DVT) in patients undergoing endoscopic endonasal surgery remains underexplored, despite its potential impact on postoperative recovery. This study aimed to develop and validate a predictive nomogram for assessing the risk of lower-limb DVT such without chemoprophylaxis. A retrospective analysis was conducted 935 with ultrasonography. Clinical data, including factors, were used construct model via multivariate logistic regression analysis. The resulting validated using...
375 Background: The combination of first-line chemotherapy and PD-1 has emerged as a standard treatment, enhancing the efficacy in advanced gastric/gastroesophageal junction (GEJ) cancer. second-line PD-1/PD-L1 remains unclear. This study aims to observe Envafolimab (PD-L1 inhibitor ) plus tyrosine kinase inhibitors (TKIs) treatment patients (pts) with GEJ adenocarcinoma. Methods: Eligible pts HER2-negative, microsatellite stable (MSS), adenocarcinoma were enrolled this study. Pts who never...