A5103443228- melanin and skin pigmentation
- Skin Protection and Aging
- Biochemical Analysis and Sensing Techniques
- Mast cells and histamine
- Regulation of Appetite and Obesity
- Stress Responses and Cortisol
- RNA regulation and disease
- Adrenal Hormones and Disorders
- Immunotherapy and Immune Responses
- Circadian rhythm and melatonin
- Olfactory and Sensory Function Studies
- Adipose Tissue and Metabolism
- Celiac Disease Research and Management
- Medicine and Dermatology Studies History
- Dye analysis and toxicity
- Acne and Rosacea Treatments and Effects
- Enzyme function and inhibition
- Retinoids in leukemia and cellular processes
- Growth Hormone and Insulin-like Growth Factors
- Garlic and Onion Studies
- Photoreceptor and optogenetics research
- Pituitary Gland Disorders and Treatments
- Cell Adhesion Molecules Research
- Receptor Mechanisms and Signaling
- Medical History and Research
University of Rochester Medical Center
2025
University of Rochester
2024
University of California, Davis
2015
Technion – Israel Institute of Technology
2000-2015
American Fisheries Society
2013
Yale University
1987-2008
Carmel Medical Center
1982-2003
New Haven Public Schools
1955-1994
University of New Haven
1981-1983
Massachusetts Eye and Ear Infirmary
1983
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTISOLATION OF MELATONIN, THE PINEAL GLAND FACTOR THAT LIGHTENS MELANOCYTES1Aaron B. Lerner, James D. Case, Yoshiyata Takahashi, Teh H. Lee, and Wataru MoriCite this: J. Am. Chem. Soc. 1958, 80, 10, 2587Publication Date (Print):May 1, 1958Publication History Published online1 May 2002Published inissue 1 1958https://pubs.acs.org/doi/10.1021/ja01543a060https://doi.org/10.1021/ja01543a060research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSTRUCTURE OF MELATONIN1Aaron B. Lerner, James D. Case, and Richard V. HeinzelmanCite this: J. Am. Chem. Soc. 1959, 81, 22, 6084–6085Publication Date (Print):November 1, 1959Publication History Published online1 May 2002Published inissue 1 November 1959https://pubs.acs.org/doi/10.1021/ja01531a060https://doi.org/10.1021/ja01531a060research-articleACS PublicationsRequest reuse permissionsArticle Views693Altmetric-Citations334LEARN ABOUT THESE...
In 1919 Atwell showed that extracts from mammalian pituitary glands darkened the skin of hypophysectomized tadpoles. Since then active principle, considered a hormone, has been known as intermedin, melanophore dilating etc., with reference to its source in intermediate lobe gland or site action, melanophores amphibia. Because term melanocyte (Fitzpatrick and Lerner, 1953, Gordon, 1953) recently was adopted name for melanin forming cell all animals, because well amphibian melanocytes are...
The enzyme tyrosinase, which catalyzes the aerobic oxidation of tyrosine to produce pigment melanin, is found widely distributed in nature.Much has been reported (1, 2) on tyrosinase obtained from plant, insect, and marine animal sources, but relatively little known concerning mammalian tyrosinase.Some years ago, Bloch his coworkers proposed, basis histochemical evidence, that melanin formation skin was attributable presence a specific whose substrate not dihydroxyphenyl-n-alanine (dopa)...
We studied the effects of prolonged ingestion melatonin, 1 g per day, on skin color and serum levels pituitary hormones in 5 human subjects with hyperpigmented skin. Melatonin lightened one patient untreated adrenogenital syndrome, but had no effect three patients' idiopathic hyperpigmentation treated Addison's disease. appeared to depress level luteinizing hormone (LH) may have inhibited some patients release growth from gland after stimulation by stress or L-dopa. The all noted increased...
IN RECENT years the relationship between hormones and mechanism of pigmentation has come to fore. In this report it will be shown that pituitary gland elaborates a melanocyte-stimulating hormone (MSH) which affects melanin in man. The "peculiar change" skin color described by Addison patients with adrenocortical insufficiency, decreased panhypopituitarism, melasma pregnancy seem depend large part upon activity MSH. Because developments leading conclusion have involved many people aspects...
HYPERPIGMENTATION in patients with adrenocortical insufficiency or some kinds of pituitary tumors is produced by increased release from the gland peptide hormones that cause melanocytes to darken.1 2 3 These peptides are melanocyte-stimulating (alpha and beta MSH) adrenocorticotrophin (ACTH). The background this subject both interesting confusing, its historical development will be pursued before our present experiments described.During period 1916–1932 it was shown intermediate lobe...