A5032315906- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Kruppel-like factors research
- Eosinophilic Disorders and Syndromes
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- Hematological disorders and diagnostics
- Liver Disease Diagnosis and Treatment
- Retinal Diseases and Treatments
- Apelin-related biomedical research
- Hemoglobinopathies and Related Disorders
- Amoebic Infections and Treatments
- Neurological Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- NF-κB Signaling Pathways
- Histone Deacetylase Inhibitors Research
- Prostate Cancer Treatment and Research
- Signaling Pathways in Disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Circular RNAs in diseases
- CNS Lymphoma Diagnosis and Treatment
- Parasitic Infections and Diagnostics
European Institute of Oncology
2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2003-2024
Ospedale San Paolo
2005-2023
University of Milan
1998-2023
Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo
2021-2022
Ospedale San Paolo
2013
Ospedale Maggiore
2003-2006
Istituti di Ricovero e Cura a Carattere Scientifico
2003-2006
Vita-Salute San Raffaele University
2002
It has been suggested that polycythemia vera (PV) could be preceded by an "early" phase of the disease (e-PV), in which increase red cell parameters is lower than required for a PV diagnosis. In this study, we compared clinicopathologic and molecular features 17 patients with e-PV those 14 essential thrombocythemia (ET) 19 PV. The results were more similar to ET. fact, characterized parameters, splenomegaly (P<.05), hepatomegaly (P=.038), together hypercellular bone marrow due increased...
We reviewed a large series of patients with essential thrombocythemia diagnosed on the basis Polycythemia Vera Study Group criteria, and reclassified them by evaluating their major morphologic features clinical course using World Health Organization classification. The review bone marrow biopsies 116 (44 males 72 females; aged 19 – 83 years, median 55 years; follow-up 121 months) led to 22 cases (19%) being classified as (ET), 24 (21%) chronic idiopathic myelofibrosis (CIMF)-0, 44 (37%)...
To identify molecular characteristics to hepatitis C virus (HCV)-associated diffuse large B-cell lymphoma (DLBCL) through a comprehensive miRNAs expression profiling.In this study, miRNA profiles were obtained from 37 patients with DLBCLs and 60 reactive lymph nodes, equally distributed according HCV presence. Germinal centres, nodes used as controls. Clinical features at presentation available for all patients.A set of 52 define signature HCV-associated DLBCL. Importantly, decreased...
Abstract Background We studied the expression of DMBT1 (deleted in malignant brain tumor 1), a putative suppressor gene, normal, proliferative, and breast epithelium its possible relation to cell cycle. Methods Sections from 17 benign lesions 55 carcinomas were immunostained with anti antibody (DMBTh12) sections 36 samples, double-stained also MCM5, one 6 pre-replicative complex proteins proliferation-licensing functions. gene at mRNA level was assessed by RT-PCR frozen tissues samples 39...
We examined 28 cases of primary bone lymphomas (PBL; stage IE) and 26 systemic involving the (SBL; IIE to IV). Two histologic types were prevalent: Diffuse large B-cell (DLBCL; PBL 21 SBL) CD30+ anaplastic cell (ALCL; 1 4 SBL). A mature B phenotype (CD45+, CD20+, CD79a+, CDw75+/-, CD10-/+) was established in DLBCL group. Bcl-2 immunoreactivity demonstrated 13/37 (35%), bcl-6 immunostaining observed 22/32 (69%). ALCL showed null/T (CD3-/+; CD43+/-; CD30+), with ALKI-1 expression 3/3 cases....
The authors investigated vascular endothelial growth factor receptor 1 (VEGFR-1) protein expression in a series of Philadelphia chromosome-negative myeloproliferative neoplasms (Ph- MPNs) and its correlations with microvessel density (MVD) (VEGF).83 bone marrow biopsies Ph- MPNs patients, including 27 essential thrombocythaemia (ET), 21 polycythaemia vera (PV) 35 primary myelofibrosis (PMF), 10 normal controls (NCs) were by immunohistochemistry.Patients PV PMF showed an increased MVD (PV:...
We evaluated the prognostic significance of vascular endothelial growth factor (VEGF) protein expression in 79 bone marrow biopsy specimens patients with myelodysplastic syndromes (MDS). VEGF levels normalized for cellularity (VEGF index [VEGFi]) were higher World Health Organization (WHO) classification-based scoring system (WPSS) "very high risk" than low group (P = .009) and MDS a poor karyotype other cytogenetic risk groups .015). High VEGFi (>75(th) percentile) predicted transfusion...
Lipoid pneumonia (LP) is a rare lung disease caused by the exposure and subsequent accumulation of lipidic substances in lung. It can be classified exogenous or endogenous acute chronic. A 42-year-old asymptomatic Caucasian female sought medical attention for incidental detection bilateral ground glass opacifications at chest CT scan. Bronchoscopy with bronchoalveolar lavage transbronchial biopsies revealed multifocal amorphous eosinophilic birefringent material lipid laden foamy alveolar...
Abstract Introduction The patient experience is recognized as a key indicator of the quality healthcare. Patients‘ expectations and experiences significantly influence health outcomes, including effects treatments in specialized settings, such cardiac surgery. Cardiovascular disease one world‘s major public problems, people who survive heart attack become ‘chronically ill‘, resulting economic costs to society. Aim aim this scoping review investigate highlight patients undergoing surgery,...
SUMMARY In myelodysplastic syndromes (MDS), bone marrow biopsy (BMB) is now considered part of a multidisciplinary approach to (BM) examination that must include cytological and cytogenetic assessment, while flow-cytometry molecular studies can provide additional useful information. Undervalued in the past, BM histology has recently grown importance terms diagnosis (i.e., MDS with fibrosis, hypoplastic MDS) prognostic assessment clusters CD34+ blasts). Thus, be complementary not overlapping...
Abstract Monitoring venous congestion by ultrasound assessment of hepatic venogram allowed individualized fluid management in severe cardiorenal syndrome type 5 due to light chain myeloma, preserving residual renal function and avoiding heart failure.
Disseminated tuberculosis is a rare form of that can cause severe illness if diagnosed and treated late. We present the case young Senegalese woman who had miscarriage due to pelvic inflammatory disease, followed by development left pleural effusion. Despite laparoscopic findings salpinx biopsy revealed necrotizing granulomas, only microbiological examinations biopsies final diagnosis disseminated, drug-sensitive tuberculosis.
You have accessJournal of UrologyCME1 Apr 2023MP80-07 MICROSCOPICAL ANALYSIS OF FRESH PROSTATE SPECIMENS: PRELIMINARY FINDINGS ABOUT NERVE DISTRIBUTION ON APEX Simone Assumma, Maria Chiara Sighinolfi, Tommaso Calcagnile, Enrico Panio, Luca Sarchi, Mattia Sangalli, Filippo Turri, Matteo Maggioni, Igor Piacentini, Paolo Marcangeli, Giulia Garelli, Daniele Stroppa, Carlo Pescia, Alessia Moro, Claudia Cigala, Cimadamore, Barabino, Giorgio Bozzini, Salvatore Micali, Angelica Grasso, Dell'Orto,...