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Jing Liu

ORCID: 0009-0007-1423-4923
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A5044694255
Research Areas
  • Chronic Lymphocytic Leukemia Research
  • CAR-T cell therapy research
  • Monoclonal and Polyclonal Antibodies Research
  • PI3K/AKT/mTOR signaling in cancer
  • Lymphoma Diagnosis and Treatment

AbbVie (United States)
 2023

 Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
OPENALEX - Publications 
Wei Li Renata Sano Mutiah Apatira Felix DeAnda Tarikere Gururaja and 10 more Muhua Yang Greta Lundgaard Chin Pan Jing Liu Yongjiao Zhai Woo Hyun Yoon Longcheng Wang Chris Tse Andrew J. Souers Chih‐Hung Lee

Abstract Small molecule inhibitors of Bruton's tyrosine kinase (BTK) have been approved for the treatment multiple B-cell malignancies and are being evaluated autoimmune inflammatory diseases. Various BTK (BTKi) distinct potencies, selectivity profiles, binding modes within ATP-binding site. On basis latter feature, BTKis can be classified into those that occupy back-pocket, H3 pocket, hinge region only. Hypothesizing differing may differential impact on receptor (BCR) signaling pathway, we...

10.1158/1535-7163.mct-22-0642 article EN cc-by-nc-nd Molecular Cancer Therapeutics 2023-09-21
 Data from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
OPENALEX - Publications 
Wei Li Renata Sano Mutiah Apatira Felix DeAnda Tarikere Gururaja and 10 more Muhua Yang Greta Lundgaard Chin Pan Jing Liu Yongjiao Zhai Woo Hyun Yoon Longcheng Wang Chris Tse Andrew J. Souers Chih‐Hung Lee

<div>Abstract<p>Small molecule inhibitors of Bruton's tyrosine kinase (BTK) have been approved for the treatment multiple B-cell malignancies and are being evaluated autoimmune inflammatory diseases. Various BTK (BTKi) distinct potencies, selectivity profiles, binding modes within ATP-binding site. On basis latter feature, BTKis can be classified into those that occupy back-pocket, H3 pocket, hinge region only. Hypothesizing differing may differential impact on receptor (BCR)...

10.1158/1535-7163.c.7005673.v1 preprint EN 2024-01-03
 Supplemental Figure 2 from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
OPENALEX - Publications 
Wei Li Renata Sano Mutiah Apatira Felix DeAnda Tarikere Gururaja and 10 more Muhua Yang Greta Lundgaard Chin Pan Jing Liu Yongjiao Zhai Woo Hyun Yoon Longcheng Wang Chris Tse Andrew J. Souers Chih‐Hung Lee

<p>Supplemental Figure 2</p>

10.1158/1535-7163.24935368 preprint NL cc-by 2024-01-03
 Supplemental Figure 3 from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
OPENALEX - Publications 
Wei Li Renata Sano Mutiah Apatira Felix DeAnda Tarikere Gururaja and 10 more Muhua Yang Greta Lundgaard Chin Pan Jing Liu Yongjiao Zhai Woo Hyun Yoon Longcheng Wang Chris Tse Andrew J. Souers Chih‐Hung Lee

<p>Supplemental Figure 3</p>

10.1158/1535-7163.24935365.v1 preprint NL cc-by 2024-01-03
 Supplementary Methods from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
OPENALEX - Publications 
Wei Li Renata Sano Mutiah Apatira Felix DeAnda Tarikere Gururaja and 10 more Muhua Yang Greta Lundgaard Chin Pan Jing Liu Yongjiao Zhai Woo Hyun Yoon Longcheng Wang Chris Tse Andrew J. Souers Chih‐Hung Lee

<p>Supplemental methods</p>

10.1158/1535-7163.24935356.v1 preprint EN cc-by 2024-01-03
 Supplemental Table 1 from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
OPENALEX - Publications 
Wei Li Renata Sano Mutiah Apatira Felix DeAnda Tarikere Gururaja and 10 more Muhua Yang Greta Lundgaard Chin Pan Jing Liu Yongjiao Zhai Woo Hyun Yoon Longcheng Wang Chris Tse Andrew J. Souers Chih‐Hung Lee

<p>Back-pocket and H3 pocket binders but not hinge-only inhibit calcium flux in Ramos TMD8 cells</p>

10.1158/1535-7163.24935359 preprint EN cc-by 2024-01-03
 Supplemental Figure 4 from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
OPENALEX - Publications 
Wei Li Renata Sano Mutiah Apatira Felix DeAnda Tarikere Gururaja and 10 more Muhua Yang Greta Lundgaard Chin Pan Jing Liu Yongjiao Zhai Woo Hyun Yoon Longcheng Wang Chris Tse Andrew J. Souers Chih‐Hung Lee

<p>Supplemental Figure 4</p>

10.1158/1535-7163.24935362.v1 preprint NL cc-by 2024-01-03
 Data from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
OPENALEX - Publications 
Wei Li Renata Sano Mutiah Apatira Felix DeAnda Tarikere Gururaja and 10 more Muhua Yang Greta Lundgaard Chin Pan Jing Liu Yongjiao Zhai Woo Hyun Yoon Longcheng Wang Chris Tse Andrew J. Souers Chih‐Hung Lee

<div>Abstract<p>Small molecule inhibitors of Bruton's tyrosine kinase (BTK) have been approved for the treatment multiple B-cell malignancies and are being evaluated autoimmune inflammatory diseases. Various BTK (BTKi) distinct potencies, selectivity profiles, binding modes within ATP-binding site. On basis latter feature, BTKis can be classified into those that occupy back-pocket, H3 pocket, hinge region only. Hypothesizing differing may differential impact on receptor (BCR)...

10.1158/1535-7163.c.7005673 preprint EN 2024-01-03
 Supplemental Table 1 from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
OPENALEX - Publications 
Wei Li Renata Sano Mutiah Apatira Felix DeAnda Tarikere Gururaja and 10 more Muhua Yang Greta Lundgaard Chin Pan Jing Liu Yongjiao Zhai Woo Hyun Yoon Longcheng Wang Chris Tse Andrew J. Souers Chih‐Hung Lee

<p>Back-pocket and H3 pocket binders but not hinge-only inhibit calcium flux in Ramos TMD8 cells</p>

10.1158/1535-7163.24935359.v1 preprint EN cc-by 2024-01-03
 Supplemental Figure 3 from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
OPENALEX - Publications 
Wei Li Renata Sano Mutiah Apatira Felix DeAnda Tarikere Gururaja and 10 more Muhua Yang Greta Lundgaard Chin Pan Jing Liu Yongjiao Zhai Woo Hyun Yoon Longcheng Wang Chris Tse Andrew J. Souers Chih‐Hung Lee

<p>Supplemental Figure 3</p>

10.1158/1535-7163.24935365 preprint NL cc-by 2024-01-03
 Supplemental Figure 1 from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
OPENALEX - Publications 
Wei Li Renata Sano Mutiah Apatira Felix DeAnda Tarikere Gururaja and 10 more Muhua Yang Greta Lundgaard Chin Pan Jing Liu Yongjiao Zhai Woo Hyun Yoon Longcheng Wang Chris Tse Andrew J. Souers Chih‐Hung Lee

<p>Supplemental Figure 1</p>

10.1158/1535-7163.24935371 preprint NL cc-by 2024-01-03
 Supplementary Methods from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
OPENALEX - Publications 
Wei Li Renata Sano Mutiah Apatira Felix DeAnda Tarikere Gururaja and 10 more Muhua Yang Greta Lundgaard Chin Pan Jing Liu Yongjiao Zhai Woo Hyun Yoon Longcheng Wang Chris Tse Andrew J. Souers Chih‐Hung Lee

<p>Supplemental methods</p>

10.1158/1535-7163.24935356 preprint EN cc-by 2024-01-03
 Supplemental Figure 4 from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
OPENALEX - Publications 
Wei Li Renata Sano Mutiah Apatira Felix DeAnda Tarikere Gururaja and 10 more Muhua Yang Greta Lundgaard Chin Pan Jing Liu Yongjiao Zhai Woo Hyun Yoon Longcheng Wang Chris Tse Andrew J. Souers Chih‐Hung Lee

<p>Supplemental Figure 4</p>

10.1158/1535-7163.24935362 preprint NL cc-by 2024-01-03
 Supplemental Figure 1 from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
OPENALEX - Publications 
Wei Li Renata Sano Mutiah Apatira Felix DeAnda Tarikere Gururaja and 10 more Muhua Yang Greta Lundgaard Chin Pan Jing Liu Yongjiao Zhai Woo Hyun Yoon Longcheng Wang Chris Tse Andrew J. Souers Chih‐Hung Lee

<p>Supplemental Figure 1</p>

10.1158/1535-7163.24935371.v1 preprint NL cc-by 2024-01-03
 Supplemental Figure 2 from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
OPENALEX - Publications 
Wei Li Renata Sano Mutiah Apatira Felix DeAnda Tarikere Gururaja and 10 more Muhua Yang Greta Lundgaard Chin Pan Jing Liu Yongjiao Zhai Woo Hyun Yoon Longcheng Wang Chris Tse Andrew J. Souers Chih‐Hung Lee

<p>Supplemental Figure 2</p>

10.1158/1535-7163.24935368.v1 preprint NL cc-by 2024-01-03
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