A5094013594- Receptor Mechanisms and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Pharmacological Effects and Assays
- Cell Adhesion Molecules Research
- Genetics and Neurodevelopmental Disorders
- Mass Spectrometry Techniques and Applications
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
Northwestern University
2024
ABSTRACT Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion molecules involved in numerous physiological functions. aGPCRs have large multi-domain extracellular regions (ECR) containing a conserved GAIN domain that precedes their seven-pass transmembrane (7TM). Ligand binding and mechanical force applied on the ECR regulate receptor function. However, how communicates with 7TM remains elusive, because relative orientation dynamics of within holoreceptor is unclear. Here, we...
Abstract Ubiquilins are a family of proteins critical to cellular proteostasis that also linked neurodegenerative diseases such as ALS, with specific mutations in UBQLN2 causing dominant, X-linked ALS. Despite an initial characterization proteasomal shuttle factors, have paradoxically been reported stabilize numerous substrates. The basis this triage decision remains enigmatic. Many other fundamental aspects Ubiquilin function unclear at the mechanistic level, physiological significance...
Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion molecules involved in numerous physiological functions. aGPCRs have large multi-domain extracellular regions (ECRs) containing a conserved GAIN domain that precedes their seven-pass transmembrane (7TM). Ligand binding and mechanical force applied on the ECR regulate receptor function. However, how communicates with 7TM remains elusive, because relative orientation dynamics of within holoreceptor is unclear. Here, we describe...