A5081352796- Glycosylation and Glycoproteins Research
- RNA and protein synthesis mechanisms
- Chromosomal and Genetic Variations
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Carbohydrate Chemistry and Synthesis
- Asthma and respiratory diseases
University of British Columbia
2020-2025
St. Paul's Hospital
2025
Massachusetts Institute of Technology
2025
Mutation or deletion of the U1 snRNP-associated factor LUC7L2 is associated with myeloid neoplasms, and knockout alters cellular metabolism. Here, we show that members LUC7 protein family differentially regulate two major classes 5' splice sites (5'SS) broadly mRNA splicing in both human cell lines leukemias copy number variation. We describe distinctive 5'SS features exons impacted by three paralogs: LUC7L enhance "right-handed" stronger consensus matching on intron side near invariant /GU,...
Asthma is a genetically complex inflammatory airway disease associated with over 200 Single nucleotide polymorphisms (SNPs). However, the functional effects of many asthma-associated SNPs in lung and epithelial samples are unknown. Here, we aimed to conduct expression quantitative trait loci (eQTL) analysis using meta-analysis nasal samples. We hypothesize that incorporating cell-type proportions enhances eQTL outcomes. Nasal brush (n=792) tissue (n=1087) were investigated separately....
Abstract Mutation or deletion of the U1 snRNP-associated factor LUC7L2 is associated with myeloid neoplasms, and knockout alters cellular metabolism. Here, we uncover that members LUC7 protein family differentially regulate two major classes 5’ splice sites (5’SS) broadly mRNA splicing in both human cell lines leukemias copy number variation. We describe distinctive 5’SS features exons impacted by three paralogs: LUC7L enhance “right-handed” stronger consensus matching on intron side...