A5101824981- Gallbladder and Bile Duct Disorders
- Pediatric health and respiratory diseases
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Immune Response and Inflammation
- Respiratory viral infections research
- Minimally Invasive Surgical Techniques
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Mechanisms and Therapy
- Molecular Biology Techniques and Applications
- Drug-Induced Hepatotoxicity and Protection
- SARS-CoV-2 detection and testing
- FOXO transcription factor regulation
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Biliary and Gastrointestinal Fistulas
- Asthma and respiratory diseases
- Parkinson's Disease Mechanisms and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Abdominal Surgery and Complications
- Vascular anomalies and interventions
- Cholesterol and Lipid Metabolism
- Balance, Gait, and Falls Prevention
Sun Yat-sen University
2024-2025
Third Affiliated Hospital of Sun Yat-sen University
2024-2025
Kaohsiung Medical University
2015-2024
Kaohsiung Medical University Chung-Ho Memorial Hospital
2015-2024
Kaohsiung Municipal Hsiao-Kang Hospital
2021-2024
Guangzhou Medical University
2023
Shanghai Stomatological Hospital
2022
National Sun Yat-sen University
2022
Xian Center for Disease Control and Prevention
2014-2016
Affiliated Hospital of Guilin Medical College
2009-2015
Multiport laparoscopic cholecystectomy is the standard surgical procedure for symptomatic gallbladder diseases. The latest evolution single incision (SILC). Single-site robotic (SSRC) overcomes several limitations of manual SILC. aim this study to present our initial experiences in SSRC and compare its clinical outcomes with those SILC.This retrospectively reviewed data patients who received or SILC from February 2014 September 2015. following variables were analyzed: age, sex, body mass...
Common bile duct (CBD) stones commonly occur in cholecystectomy cases. Management options include laparoscopic common exploration (LCBDE) or endoscopic retrograde cholangiopancreatography (ERCP) followed by (LC). While ERCP is mature, it has complications, and LCBDE a proven alternative. This study evaluates the safety efficacy of these treatments elderly individuals aged 70 older. A retrospective from January 2015 to July 2022 included 160 patients (aged older) diagnosed with cholelithiasis...
ABSTRACT Background The exact nature of the link between breast cancer and meningiomas is unknown, although observational studies have shown a correlation two. Using two‐sample Mendelian randomization (MR) strategy, we aimed to investigate effect on meningiomas. Methods Three sets genetic instruments were utilized in this study based publicly available summary data. For cancer, selected 62 strongly associated SNPs; separate datasets curated for HER2‐positive HER2‐negative subtypes. MR...
We investigated a diarrhea outbreak that occurred at university in China to identify the etiological agent of outbreak, source infection, mode transmission, and risk factors.In this case-control study, we compared food sources examined water items consumed between probable confirmed cases asymptomatic control students, who were selected randomly frequency-matched by class age ratio 1:2.Out 7141 students (excluding teachers), 87 (1.2%) developed an illness. Thirty-three 44 (75%) 11 88 (13%)...
Regorafenib is a multikinase inhibitor that was approved by the US Food and Drug administration in 2017. Cancer stem cells (CSCs) are small subset of cancer-initiating thought to contribute therapeutic resistance. The forkhead box protein M1 (FOXM1) plays an important role regulation stemness CSCs mediates resistance chemotherapy. However, relationship between FOXM1 regorafenib liver cancer remains unknown. We found regorafenib-resistant HepG2 clones overexpressed various markers CSCs....
Noroviruses (NoV) have been recognized as an important pathogen associated with acute gastroenteritis worldwide during the past three decades. In spring of 2012, a series foodborne outbreaks in tourist groups were reported to Xiamen Center for Disease Control and Prevention, Xiamen, Fujian province, China. Among total 268 tourists 7 groups, prevalence rate was 16.0% (43/268). Twenty-three feces or anal swabs collected laboratory tests causative agents, no bacterial identified, while 22 them...
We investigated a diarrhea outbreak in 2 universities to identify the etiological agent responsible, source of infection, mode transmission, and risk factors. A case-controlled study was conducted using case students asymptomatic control who were selected randomly frequency-matched according class age, food or water intake investigated. Of total 22,404 at universities, 0.25% developed Salmonella Infections. 96% (54/56) 30% (35/117) consumed bread products provided by same vendor (odds ratio...
BACKGROUND: Effective prognostic biomarkers and powerful target-therapeutic drugs are needed for improving the treatment of Hepatocellular carcinoma (HCC).OBJECTIVE: This study aimed to evaluate expression FOXM1 Aurora-A their value in HCC.METHODS: We determined differentially expressed genes signature HCC using Gene Set Enrichment Analysis (GSEA), then evaluated TCGA KMUH cohort.Associations between co-expression clinical variables were calculated.Overall survival (OS) recurrence-free (RFS)...
Staphylococcus aureus is a global epidemic pathogen that causes heavy disease burden. The aim of this study was to determine which globally known S. lineages are currently present in hospital Xiamen. Therefore, the 426 strains were detected by Melting Curve Analysis (MCA) and genotyped Pulsed Field Gel Electrophoresis (PFGE) as well Multicolor Analysis-Based Multilocus Melt Typing (MLMT). In addition, Sequence (MLST) used identify 108 representative strains. light eighteen antibiotics except...
If portal vein stenosis (PVS) occurs within 1 month after liver transplantation (LT), especially week, it can be catastrophic and result in rapid loss of the grafts mortality. Although surgical treatments have been considered standard treatment for PVS, patients are usually unable to receive operations or re-transplantations, because their critical conditions a shortage grafts. Recently, primary percutaneous transhepatic stents (PTPS) were suggested as alternative less-invasive PVS. However,...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with no effective treatments available. There growing evidence that cuproptosis contributes to the pathogenesis of this disease. This study developed novel molecular clustering based on cuproptosis-related genes and constructed signature for AD patients.
Enterovirus 71 (EV71) is the causative agent of hand, foot and mouth disease can spread its infections to central nervous other systems with severe consequences. The replication EV71 depends on 3C proteinase (3Cpro ), a significant drug target. By X-ray crystallography functional assays, interactions between inhibitors 3Cpro were evaluated. It was shown that improved at S4 for substrate binding could significantly enhance potency. A new series potent high ligand efficiency generated...
Liver failure, including acute-on-chronic liver failure (ACLF), occurs mainly in young adults and is associated with high mortality resource costs. The prognosis evaluation a crucial part of the ACLF treatment process should run through entire diagnosis process. As recently proposed novel algorithm, quantitative difference (QD) algorithm holds promise for enhancing ACLF.This study aims to examine whether QD exhibits comparable or superior performance compared Model End-Stage Disease (MELD)...
Few studies have compared percutaneous biliary stenting (PBS) and endoscopic (EBS) in terms of long-term effects on cholangiocarcinoma (CC), few systematically evaluated outcome associations Taiwan. This study aimed to compare outcomes between two treatments for unresectable CC: PBS EBS. After propensity score matching (PSM) reduce the effect selection bias, 1002 CC patients were included this analysis: 501 group EBS group. The Kaplan-Meier method was used construct survival curve all...
The accumulation of β-sheet-rich α-synuclein (α-Syn) protein in human brain cells is a pathological hallmark Parkinson's disease (PD). Moreover, it has been reported that familial PD mutations (A30P, E46K, H50Q, G51D, and A53T) accumulate at an accelerated rate both vivo vitro. In addition, accumulations various C-terminal α-Syn truncations, such as C-terminal-truncated N103 (N103), were found aggregated form the tissue patients. Fluorescent protein-tagged wild-type α-Syn, A30P, A53T,...