A5048019002- CAR-T cell therapy research
- Nanowire Synthesis and Applications
- Polyomavirus and related diseases
- Tumors and Oncological Cases
- Cancer and Skin Lesions
- Virus-based gene therapy research
Hospital Universitario 12 De Octubre
2025
Research Institute Hospital 12 de Octubre
2025
Instituto de Investigación Marqués de Valdecilla
2023
Background CD19-directed cancer immunotherapies, based on engineered T cells bearing chimeric antigen receptors (CARs, CAR-T cells) or the systemic administration of bispecific cell-engaging (TCE) antibodies, have shown impressive clinical responses in relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, more than half patients relapse after TCE therapy, with escape lineage switching accounting for one-third disease recurrences. To minimize tumor escape, dual-targeting...
Epithelial transdifferentiation is frequent in tissue hyperplasia and contributes to disease various degrees. Squamous metaplasia (SQM) precedes epidermoid lung cancer, an aggressive malignancy, but it rare the epithelium of mammary gland. The mechanisms leading SQM have been very poorly investigated. We studied this issue on human freshly isolated cells organoids. Here we show that or strikingly undergo with polyploidisation when they are exposed genotoxic mitotic drugs, such as Doxorubicin...