A5101435400- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Toxic Organic Pollutants Impact
- RNA Interference and Gene Delivery
- Environmental Impact and Sustainability
- Global Energy and Sustainability Research
- Environmental Toxicology and Ecotoxicology
- RNA Research and Splicing
- Renal and related cancers
- Biochemical and biochemical processes
- Spectroscopy Techniques in Biomedical and Chemical Research
- Single-cell and spatial transcriptomics
- Nitric Oxide and Endothelin Effects
- Cancer-related gene regulation
- Erythrocyte Function and Pathophysiology
- Gene expression and cancer classification
- Sustainability and Ecological Systems Analysis
- Microbial Metabolic Engineering and Bioproduction
- Per- and polyfluoroalkyl substances research
- Water Resources and Sustainability
- 14-3-3 protein interactions
- Autophagy in Disease and Therapy
Sun Yat-sen University
2015-2024
Shanghai Ninth People's Hospital
2024
Shandong Agricultural University
2023
BGI Research
2023
Hunan University
2020-2023
State Key Laboratory of Chemobiosensing and Chemometrics
2020-2023
Obstetrics and Gynecology Hospital of Fudan University
2015-2023
Hainan Marine Monitoring and Forecasting Center
2023
China National GeneBank
2023
Air Force Communication NCO Academy
2022
Abstract Recent technological developments in spatial transcriptomics allow researchers to measure gene expression of cells and their locations at the single-cell level, generating detailed biological insight into processes. A comprehensive database could facilitate sharing transcriptomic data streamline acquisition process for researchers. Here, we present Spatial TranscriptOmics DataBase (STOmicsDB), a that serves as one-stop hub transcriptomics. STOmicsDB integrates 218 manually curated...
MicroRNAs (miRNAs) have emerged as promising diagnostic biomarkers and therapeutic targets in various diseases. However, there is currently a lack of molecular strategies that can effectively use disease-associated extracellular miRNAs input signals to drive functions. Herein, we present modular programmable miRNA-responsive chimeric DNA receptor (miRNA-CDR) capable biomarker-driven therapy. By grafting nanodevice on natural membrane via aptamer anchoring, miRNA-CDR sense miRNA levels...
Abstract Background Deregulation of integrins signaling had been documented to participate in multiple fundamental biological processes, and the aberrant expression integrin family members were linked prognosis various cancers. However, role predicting progression ovarian cancer patients are still largely elusive. This study is aimed explore prognostic values ITGA ITGB superfamily high grade serous cancers (HGSOC). Methods GSE26712 dataset was used determine differential member between HGSOC...
Polyhalogenated carbazoles (PHCZs) are dioxin-like emerging contaminants, but limited information exists on their neurotoxicity and mechanisms. This study employed zebrafish embryos to investigate the adverse effects of 3-bromocarbazole (3-BCZ), a typical PHCZ, exposure in early life stages found that 120 h post fertilization (hpf)-median lethal concentration (LC50) value 3-BCZ larvae was 2.88 mg/L. The results revealed inhibited tail coiling at ≥0.06 mg/L, decreased hatchability ≥2.88...
Endometrial carcinoma is the second most common gynecological malignancy of female genital tract worldwide. Enhancer zeste homolog 2 (EZH2), a critical component polycomb repressive complex 2, has been found to be involved in multiple biological processes and overexpressed several types cancer. Previous studies have demonstrated that EZH2 associated with endometrial carcinoma. The present study showed was hyperplasia, atypical hyperplasia cancer, but not simple normal endometrium....
Chilling stress seriously impairs photosynthesis and activates a series of molecular responses in plants. Previous studies have shown that ETHYLENE INSENSITIVE 3 (EIN3) EIN3-like (SlEIL) proteins mediate ethylene signaling reduce plant tolerance to freezing tomato (Solanum lycopersicum). However, the specific mechanisms underlying an EIN3/EILs-mediated photoprotection pathway under chilling are unclear. Here, we discovered salicylic acid (SA) participates photosystem II (PSII) protection via...
The precise regulation of fundamental cellular behaviors, such as cell adhesion, proliferation, migration, differentiation, and cell-cell interactions, is essential in multicellular organisms. behaviors largely relies on the receptor-mediated sensing transduction extracellular ligands. manipulation ligand-induced receptor activation via molecular engineering approaches will offer insight into physiological processes, facilitating rational design cell-based therapeutics to treat diseases. DNA...
Bevacizumab (BEV), the most common antiangiogenic agent for treating ovarian cancer, prolongs progression-free survival (PFS) but does not significantly improve overall (OS). Improving limited clinical benefit of BEV remains a major challenge in cancer treatment. Although several studies have explored mechanisms underlying tumor resistance to BEV, translation these findings overcome has been limited. To identify key molecules and that modulate sensitivity BEV. RNA sequencing was conducted on...
// Nan Jia 1, 3, * , Jieyu Wang Qing Li 3 Xiang Tao 2 Kaikai Chang Keqin Hua Yinhua Yu Kwong-Kwok Wong 4 Weiwei Feng 1 Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China Pathology, Shanghai Key Laboratory Female Reproductive Endocrine-Related Disease, Gynecologic Oncology Medicine, The University Texas MD Anderson Cancer Center, Houston, TX, USA These authors have contributed equally to this work Correspondence to: Feng, email:...
The overall survival rate of patients with advanced ovarian cancer (OC) has remained static for several decades. Advanced is known its poor prognosis due to extensive metastasis. Epigenetic alterations contribute tumour progression and therefore are interest potential therapeutic strategies.Following our previous study, we identified that CHD4, a chromatin remodelling factor, plays strong role in cell We investigated the clinical significance CHD4 through TCGA GEO database analyses explored...
Abstract MicroRNAs (miRNAs) have emerged as promising diagnostic biomarkers and therapeutic targets in various diseases. However, there is currently a lack of molecular strategies that can effectively use disease‐associated extracellular miRNAs input signals to drive functions. Herein, we present modular programmable miRNA‐responsive chimeric DNA receptor (miRNA‐CDR) capable biomarker‐driven therapy. By grafting nanodevice on natural membrane via aptamer anchoring, miRNA‐CDR sense miRNA...
Background: Human paired box 2 (PAX2) plays a key role in cell fate, early patterning and organogenesis. Methods: We investigated the function of PAX2 on biological behavior endometrial cancer vitro vivo to explore regulation mechanism, stable knocking-down over-expression lines were established. CCK-8 transwell assays applied determine proliferation, invasion migration ability. Cell cycle distribution was analyzed by flow cytometry. Affymetrix GeneChip® human Exon 1.0 ST arrays used screen...
Hyperosmotic stress may be initiated during a diverse range pathological circumstances, which in turn results tissue damage. In this process, the activation of survival signaling, has capacity to restore cell homeostasis, determines fate. Autophagy is responsible for and activated by various stimuli. However, its interplay with hyperosmotic effect on terminally differentiated cardiac myocytes unknown. Nuclear factor T‑cells 5 (NFAT5), an osmo‑sensitive transcription factor, mediates...
Objective: Recently, accumulating evidence has indicated that the 3' untranslated regions (3'UTRs) of protein coding genes play critical roles in progression various cancers, including ovarian cancer. This study is aimed to identify potential role SNAI2-3'UTR ovarain cancer progression. Study Design: First, we tried explore clinical significance SNAI2 using TCGA and GSE26712 dataset. Then, gain-of-function studies were performed establish invasion migration cells. Finally, efforts made...
Hydrolytic activity for chlorogenic acid (CGA) has been recognized as an important side of some types ferulic esterases. The purpose this work was to enhance the efficient expression esterase (FAE) and explore its application in processing sunflower seed. Two novel FAEs from Aspergillus aculeatus (AaSD14) were expressed genetically engineered E. coli BL21 (DE3), their properties, including temperature, pH, metal ions substrate specificity, characterized after purification. Competitive CGA...
<title>Abstract</title> This study aimed to elucidate the mechanisms of innervation-associated competing endogenous RNAs (ceRNAs) in grafted bone, a subject remaining uncharted field bone innervation. Osteoporosis is prevalent complication following mandibular reconstruction, significantly affecting success rate and quality life patients with postoperative implants. Utilizing transcriptome sequencing technology, we examined innervation-nurtured (IN), reestablished nerve-supply graft (RN),...
Abstract Human paired box 2 (PAX2) plays a key role in cell fate, early patterning and organogenesis. To investigate the function of PAX2 on biological behavior endometrial cancer regulation mechanism, stable knocking-down over-expression lines were established. CCK-8 transwell assays applied to determine proliferation, invasion migration ability. Cell cycle distribution was analyzed by flow cytometry. Nude mice used for vivo experiments Affymetrix GeneChip® human Exon 1.0 ST arrays screen...