A5020794373- Estrogen and related hormone effects
- Software Testing and Debugging Techniques
- Steroid Chemistry and Biochemistry
- CRISPR and Genetic Engineering
- Fungal and yeast genetics research
- Advanced Malware Detection Techniques
- Advanced Software Engineering Methodologies
- Genomics and Chromatin Dynamics
- Adversarial Robustness in Machine Learning
- Chromosomal and Genetic Variations
- Healthcare Technology and Patient Monitoring
- Gout, Hyperuricemia, Uric Acid
- Endoplasmic Reticulum Stress and Disease
- Plant biochemistry and biosynthesis
- Sphingolipid Metabolism and Signaling
- Botulinum Toxin and Related Neurological Disorders
- RNA modifications and cancer
- Heat shock proteins research
- Signaling Pathways in Disease
- Neurotransmitter Receptor Influence on Behavior
- Human-Automation Interaction and Safety
- Software Reliability and Analysis Research
- Genetics, Aging, and Longevity in Model Organisms
- Lysosomal Storage Disorders Research
- Cardiomyopathy and Myosin Studies
University of Notre Dame
1985-2024
Michigan Medicine
2019
Emory University
2014-2016
University of Massachusetts Amherst
2009
University of Michigan
2005
Wadsworth Center
1997
University at Albany, State University of New York
1997
Significance Human susceptibility to gout is driven by the fact that we have a pseudogene for uricase prevents functional enzyme from being produced. Our inability convert highly insoluble uric acid into more soluble molecule makes us vulnerable disease and other health complications. We exploited ancestral sequence reconstruction better understand how why apes lost this enzyme. ancient proteins support one hypothesis progressive loss of activity allowed our ancestors readily accumulate fat...
We demonstrate that in Saccharomyces cerevisiae, the tandem array of ribosomal RNA genes (RDN1) is a target for integration Ty1 retrotransposon results silencing transcription and transposition. elements transpose into random rDNA repeat units are mitotically stable. In addition, we have found mutation several putative modifiers RDN1 chromatin structure abolishes array. Disruption SIR2, which elevates recombination RDN1, or TOP1, increases psoralen accessibility rDNA, HTA1-HTB1, reduces...
Autotaxin is the enzyme responsible for production of lysophosphatidic acid (LPA) from lysophosphatidyl choline (LPC), and it up-regulated in many inflammatory conditions, including but not limited to cancer, arthritis, multiple sclerosis. LPA signaling causes angiogenesis, mitosis, cell proliferation, cytokine secretion. Inhibition autotaxin may have anti-inflammatory properties a variety diseases; however, this hypothesis has been tested pharmacologically because lack potent inhibitors....
The MAPE-K feedback loop has been established as the primary reference model for self-adaptive and autonomous systems in domains such driving, robotics, Cyber-Physical Systems. At same time, Human Machine Teaming (HMT) paradigm is designed to promote partnerships between humans machines. It goes far beyond degree of collaboration expected human-on-the-loop human-in-the-loop emphasizes interactions, partnership, teamwork However, while enables fully behavior, it does not explicitly address...
Small Unmanned Aerial Systems (sUAS) must meet rigorous safety standards when deployed in high-stress emergency response scenarios; however many reported accidents have involved humans the loop. In this paper, we, therefore, present HiFuzz testing framework, which uses fuzz to identify system vulnerabilities associated with human interactions. includes three distinct levels that progress from a low-cost, limited-fidelity, large-scale, no-hazard environment, using fully simulated Proxy Human...
Motor proteins that translocate on nucleic acids are key players in gene expression and maintenance.While the function of these is diverse, they driven by highly conserved core motor domains.In transcription-coupled DNA repair, activity serves to remove RNA polymerase stalled damaged DNA, making lesion accessible for repair.Structural biochemical data bacterial transcription-repair coupling factor Mfd suggest this enzyme undergoes large conformational changes from a dormant state an active...
Small Unmanned Aerial Systems (sUAS) must meet rigorous safety standards when deployed in high-stress emergency response scenarios; however many reported accidents have involved humans the loop. In this paper, we, therefore, present HiFuzz testing framework, which uses fuzz to identify system vulnerabilities associated with human interactions. includes three distinct levels that progress from a low-cost, limited-fidelity, large-scale, no-hazard environment, using fully simulated Proxy Human...
Recent studies in multiple organisms identify pathways that link the perception of stress by nervous system with signaling networks modify health and longevity. Several these longevity involve monoamine neurotransmitter serotonin as a key molecule. With knowledge plays critical role regulating aging, our current research focuses on using C. elegans to understand map how neuronal signal improve long-term health. Our previous work showed induction flavin -containing monooxygenase-2 (fmo-2),...