A5103225702- Nuclear physics research studies
- Nuclear Physics and Applications
- Gene expression and cancer classification
- Enzyme Catalysis and Immobilization
- Gut microbiota and health
- Chemical synthesis and alkaloids
- Analytical Chemistry and Chromatography
- Atomic and Subatomic Physics Research
- Nuclear reactor physics and engineering
- Geology and Paleoclimatology Research
- Bayesian Methods and Mixture Models
- Fungal Biology and Applications
- Radiation Detection and Scintillator Technologies
- Bioinformatics and Genomic Networks
- Microbial Metabolites in Food Biotechnology
- Plant Pathogens and Fungal Diseases
- Fluoride Effects and Removal
- Microbial Metabolic Engineering and Bioproduction
- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Molecular Biology Techniques and Applications
- Quantum Chromodynamics and Particle Interactions
- Quantum, superfluid, helium dynamics
- Plant tissue culture and regeneration
- Dental Radiography and Imaging
RIKEN BioResource Research Center
2020-2024
University of Shizuoka
2021-2024
Osaka University
2014-2024
Utsunomiya University
2022-2024
Bioscience Research
2024
Tokyo University of Agriculture and Technology
2017-2022
Niigata University
2003-2022
Tokyo Institute of Technology
2020-2021
RIKEN Nishina Center
2020-2021
The University of Tokyo
2021
Lignin conversion to value-added products is one of the most attractive challenges develop a complete system for lignocellulosic biomass utilization. The objective this study was cis,cis-muconic acid (ccMA) production from lignin, in particular, without sugar. Here, two bacterial strains were developed that can synthesize ccMA lignin using glucose. One applicable softwood (mostly guaiacyl-lignin), and other hardwood syringyl- guaiacyl-lignins). engineered Pseudomonas putida KT2440-based...
Both inorganic fertilizer inputs and crop yields have increased globally, with the concurrent increase in pollution of water bodies due to nitrogen leaching from soils. Designing agroecosystems that are environmentally friendly is urgently required. Since highly complex consist entangled webs interactions between plants, microbes, soils, identifying critical components production remain elusive. To understand network structure engineered by several farming methods, including soil...
Lactoferrin is an iron-binding glycoprotein found in the milk of most mammals for which various biological functions have been reported, such as antimicrobial activity and bifidogenic activity. In this study, we compared bovine lactoferrin (bLF) pepsin hydrolysate bLF (bLFH), isolated peptide from bLFH, investigated spectra bLF, its active against 42 bifidobacterial strains comprising nine species. Against Bifidobacterium breve ATCC 15700(T), minimal effective concentrations bLFH were 300 10...
Opencast nickel mining is common in natural forests of Indonesia. However, rehabilitation postmining degraded land difficult. We investigated the effect opencast on soil chemical properties and growth two fast-growing tropical tree species, Falcataria moluccana Albizia saman. Soil was collected from post-nickel a nearby forest. pH, available phosphorus (P) concentration, total carbon (TC) nitrogen (TN) C/N ratio, cation exchange capacity (CEC), exchangeable K, Na, Mg, Ca, Fe, Ni...
Intermediate omics traits, which mediate the effects of genetic variation on phenotypic are increasingly recognised as valuable components evaluation. In particular, rhizosphere microbiota play a crucial role in plant health and productivity; however, their complex interactions with host genetics remain challenging to model. Although two-step modeling frameworks have been proposed integrate intermediate traits into phenotype prediction, existing approaches do not incorporate nonlinear...
Reduction of 1-phenyl-1, 2-propanedione with baker's yeast afforded (1R, 2S)-1-phenyl-1, 2-propanediol in high chemical and optical yield. 2S)-, 2R)- (1S, 2S)-1, 2-propanediols were also prepared via (1R)- or (2S)-α-ketols, which obtained as intermediates the above reaction.
The remediation of opencast bauxite mines in the natural forests Indonesia is difficult. We have investigated and contrasted chemical characteristics soils from mining sites their effects on plant growth. soil pH, total carbon (C), nitrogen (N) available phosphorus (P) concentrations, cation exchange capacity, C/N ratio, exchangeable K, Na, Mg, Ca, Fe, Ni concentrations were determined. Falcataria moluccana Albizia saman then grown these for 15 weeks, shoot heights, dry weights, root weights...
Synthesis of optically active hetero alkylaryl alcohols have been examined using baker's yeast.The use yeast (Saccharomyces cerevisiae) in organic synthesis provides efficient access to the chiral synthons.In course transformation with yeast, various substrates were submitted give versatile compounds,but applications this substrates, that aromatic heterocycles, are not so many reported.lr2NOW, weinvestigated thesynthesis synthons which ring based on its reductive and hydrolytic abilities.
In veterinary medicine, congenital methemoglobinemia associated with nicotinamide adenine dinucleotide (NADH)-cytochrome b5 reductase (b5R) deficiency is rare. It has been reported in several breeds of dogs, but little information available about its etiology.To analyze the NADH-cytochrome gene, CYB5R3, a Pomeranian dog family suspected to be caused by b5R deficiency.Three dogs from were analyzed. Five healthy beagles and 5 nonrelated without used as controls.Methemoglobin concentration,...
Although cytochromes P450 2C9 (CYP2C9) and 2C19 (CYP2C19) have 91% amino acid identity, they different substrate specificities. Previous studies suggested that several residues may be involved in specificity. In this study, we focused on the roles of two acids, 72 241. The acids these positions opposite charges CYP2C9 2C19; former has lysines both (Lys72 Lys241), latter glutamic (Glu72 Glu241). Reciprocal mutants for CYP2C19 were produced, their metabolic activities spectroscopic properties...
The gyromagnetic factor of the low-lying E=251.96(9) keV isomeric state nucleus ^{99}Zr was measured using time-dependent perturbed angular distribution technique. This level is assigned a spin and parity J^{π}=7/2^{+}, with half-life T_{1/2}=336(5) ns. isomer produced aligned via abrasion-fission ^{238}U primary beam at RIKEN RIBF. A magnetic moment |μ|=2.31(14)μ_{N} deduced showing that this not single particle in nature. comparison experimental values interacting boson-fermion model...
The attainment of a good aesthetic outcome in dental implant treatment requires inter-implant papilla reconstruction, which is very difficult to perform. Maintenance the bone essential for maintenance papilla. aim this study was investigate mechanical influences implant–abutment connection type and distance on by using three-dimensional finite element analysis. Three computer-aided design models two-piece implants were designed: external (EC), internal (IC), conical (CC). In each model, two...
Poultry red mites (Dermanyssus gallinae, PRMs), tropical fowl (Ornithonyssus bursa, TFMs), and northern (O. sylviarum, NFMs) are blood-feeding pests that debilitate poultry worldwide. Glutathione S-transferase (GST) plays an important role in the detoxification drug metabolism of mites. However, research on avian mite GSTs as vaccine antigens is still lacking. Therefore, we aimed to evaluate potential for development. We identified GST genes from TFMs NFMs. prepared recombinant (rGST) TFMs,...
Pregnane X receptor (PXR) is a xenobiotic-sensing nuclear that plays key role in drug metabolism. Recently, PXR was found to attenuate the development of liver cancer by suppressing epithelial-mesenchymal transition (EMT) cells mouse model two-stage chemical carcinogenesis. To elucidate EMT cells, we focused on its hepatic stellate (HSCs), which are components tumor microenvironment hepatocellular carcinoma (HCC). Human HSC-derived LX-2 stably expressed destabilization domain (DD)-fused...
<title>Abstract</title> High-dimensional multi-omics microbiome data plays an important role in elucidating microbial communities’ interactions with their hosts and environment critical diseases ecological changes. Although Bayesian clustering methods have recently been used for the integrated analysis of data, no method designed to analyze has proposed. In this study, we propose a novel framework called integrative stochastic variational variable selection (I-SVVS), which is extension...
Poultry red mites (PRMs, Dermanyssus gallinae) are harmful ectoparasites that affect farmed chickens and cause serious economic losses in the poultry industry worldwide. Acaricides used for PRM control; however, some PRMs have developed acaricide-resistant properties, which indicated need different approaches control. Therefore, it is necessary to elucidate biological status of develop alternative control strategies. Quantitative polymerase chain reaction (qPCR) allows analysis at transcript...
Pregnane X receptor (PXR) plays an important role in xenobiotic metabolism. While ligand binding induces PXR-dependent gene transcription, PXR shows constitutive transcriptional activity the absence of ligands when expressed cultured cells. This sometimes hampers investigation activation by compounds interest. In this study, we investigated molecular mechanism activation. reported crystal structures unliganded PXR, helix 12 (H12), including a coactivator motif, was stabilized, while it is...