A5071664719- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Pharmacological Effects of Natural Compounds
- Cardiac electrophysiology and arrhythmias
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Circadian rhythm and melatonin
Osong Medical Innovation Foundation
2024
Chungbuk National University
2022-2024
Intracranial self-stimulation (ICSS) of the medial forebrain bundle in mice is an experimental model use to assess relative potential reward-seeking behaviors. Here, we used ICSS evaluate abuse 18 abused drugs: 3-Fluoroethamphetamine (3-FEA); methylphenidate; cocaine; dextroamphetamine; alpha-Pyrrolidinobutyrophenone (α-PBT); 4'-Fluoro-4-methylaminorex (4-FPO); methamphetamine; larocaine; phentermine; paramethoxymethamphetamine (PMMA); phendimetrazine;...
Glutamic acid decarboxylase 67 (GAD67) is a gamma-aminobutyric (GABA) synthesis enzyme associated with the function of other neurotransmitter receptors, such as N-methyl-D-aspartate (NMDA) receptor and cannabinoid 1. However, role GAD67 in development different abused drug-induced reward behaviors remains unknown. In order to elucidate mechanisms substance use disorder, it crucial study changes biomarkers within brain's circuit induced by drug use.
Over the past decade, new psychoactive substances (NPS) have emerged in illegal drug market and continued to attract attention from international community. Among these, amphetamine-like NPS, classified as stimulants, constitute a significant proportion. However, pharmacological characteristics mechanisms underlying addiction NPS remain poorly understood. Given that circadian rhythms are linked brain stimulation effects of methamphetamine (METH) amphetamine, we investigated METH,...
Abstract The use of many benzodiazepines is controlled worldwide due to their high likelihood abuse and potential adverse effects. Flubromazepam—a designer benzodiazepine—is a long-acting gamma-aminobutyric acid subtype A receptor agonist. There currently lack scientific evidence regarding the for flubromazepam dependence or other This study aimed evaluate potential, cardiotoxicity via confirmation QT RR intervals which are factors on electrical properties heart in rodents. Using conditioned...