A5080589812- Pharmacogenetics and Drug Metabolism
- RNA Interference and Gene Delivery
- Curcumin's Biomedical Applications
- Estrogen and related hormone effects
- Phytochemicals and Medicinal Plants
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Protein Hydrolysis and Bioactive Peptides
- Cancer Treatment and Pharmacology
- Tannin, Tannase and Anticancer Activities
- Drug Transport and Resistance Mechanisms
- Hormonal Regulation and Hypertension
- Phytochemical compounds biological activities
- Prostate Cancer Treatment and Research
University of Bern
2024-2025
University Children’s Hospital Bern
2024-2025
University Hospital of Bern
2025
Universidade Nova de Lisboa
2022
The altered activity of drug metabolism enzymes (DMEs) is a hallmark chemotherapy resistance. Cytochrome P450s (CYPs), mainly CYP3A4, and several oxidoreductases are responsible for Phase I doxorubicin (DOX), an anthracycline widely used in breast cancer (BC) treatment. This study aimed to investigate the role DMEs involved first stages acquisition DOX-resistance BC cells. For this purpose, expression 92 DME genes specific CYP-complex activities were assessed either sensitive (MCF-7 parental...
Progesterone receptor membrane component 1 (PGRMC1) is one of few proteins that have been recently described as direct modulators the activity human cytochrome P450 enzymes (CYP)s. These form a superfamily membrane-bound hemoproteins metabolize wide variety physiological, dietary, environmental, and pharmacological compounds. Modulation CYP impacts detoxification xenobiotics well endogenous pathways such steroid fatty acid metabolism, thus playing central role in homeostasis. This review...
Abstract Disclosure: I.S. Barata: None. J. Yakubu: T. Du Toit: A.V. Pandey: Supplements derived from plant extracts are often used as alternatives to pharmaceutical drugs. These products perceived safe despite the absence of scientific evidence regarding their efficacy and safety less strictly regulated than products. Winter cherry (Withania somnifera, commonly known ashwagandha) is a testosterone booster supplement in multiple countries. Withania somnifera extract was found increase...
Abstract Disclosure: I.S. Barata: None. J. Yakubu: T. Du Toit: A.V. Pandey: Supplements derived from plant extracts are often used as alternatives to pharmaceutical drugs. These products perceived safe despite the absence of scientific evidence regarding their efficacy and safety less strictly regulated than products. Winter cherry (Withania somnifera, commonly known ashwagandha) is a testosterone booster supplement in multiple countries. Withania somnifera extract was found increase...
<title>Abstract</title> Endogenous androgens are pivotal in the development and progression of prostate cancer (PC). We investigated nanoparticle formulations curcumin piperine modulating steroidogenesis within PC cells. Using multiple cell lines (LNCaP, VCaP, DU145 PC3) we studied effects curcumin, piperine, their formulations—curcumin nanoparticles, curcumin-piperine nanoparticles (CPN)—on viability, migration, steroid biosynthesis. Curcumin its significantly reduced viability cells, with...
Abstract Endogenous androgens are pivotal in the development and progression of prostate cancer (PC). We investigated nanoparticle formulations curcumin piperine modulating steroidogenesis within PC cells. Using multiple cell lines (LNCaP, VCaP, DU145 PC3) we studied effects curcumin, piperine, their formulations—curcumin nanoparticles, curcumin-piperine nanoparticles (CPN)—on viability, migration, steroid biosynthesis. Curcumin its significantly reduced viability cells, with showing highest...
Endogenous androgens are pivotal in the development and progression of prostate cancer (PC). We investigated nanoparticle formulations curcumin piperine modulating steroidogenesis within PC cells. Using multiple cell lines (LNCaP, VCaP, DU145 PC3) we studied effects curcumin, piperine, their formulations&mdash;curcumin nanoparticles, curcumin-piperine nanoparticles (CPN)&mdash;on viability, migration, steroid biosynthesis. Curcumin its significantly reduced viability cells, with...