A5117099666- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Antioxidant Activity and Oxidative Stress
The Ohio State University Wexner Medical Center
2025
Ozone (O3) is an air pollutant that induces pulmonary inflammation and injury, leading to increased susceptibility exacerbation of chronic lung diseases. Furthermore, ambient O3 levels are expected rise with increasing global temperatures. Docosahexaenoic acid (DHA) omega-3 (n-3) polyunsaturated fatty (PUFA) primarily found in oily fish reduces enhances the resolution inflammation. This partially attributed DHA-derived oxylipins termed specialized pro-resolving mediators (SPMs) have...
ABSTRACT Ozone (O 3 ) is a toxic air pollutant that causes pulmonary inflammation, neutrophil recruitment, and lung injury. Part of the inflammatory response to O includes altered expression formyl peptide receptor 2 (ALX/FPR2), G protein‐coupled expressed primarily in immune cells. ALX/FPR2 considered either anti‐inflammatory/proresolving or proinflammatory depending on its ligands, which include lipoxin A4 serum amyloid A (SAA). While ligand has been well studied, there remains significant...