A5083263206- Cardiac, Anesthesia and Surgical Outcomes
- CRISPR and Genetic Engineering
- Virus-based gene therapy research
- Trace Elements in Health
- Thyroid Cancer Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Enhanced Recovery After Surgery
- Adenosine and Purinergic Signaling
- RNA regulation and disease
- Medicinal Plant Pharmacodynamics Research
- Calcium signaling and nucleotide metabolism
- Pharmacogenetics and Drug Metabolism
- Airway Management and Intubation Techniques
- Clinical Nutrition and Gastroenterology
- Chromatography in Natural Products
- Intestinal and Peritoneal Adhesions
- Cardiac Arrest and Resuscitation
- Xenotransplantation and immune response
- Intestinal Malrotation and Obstruction Disorders
- Cardiac tumors and thrombi
- Renal cell carcinoma treatment
- Cardiac Valve Diseases and Treatments
- Pharmaceutical and Antibiotic Environmental Impacts
- Plant Disease Management Techniques
- Cancer Cells and Metastasis
Chongqing Medical University
2025
Mayo Clinic in Florida
2025
Duke University
2023-2024
University of Calgary
2007-2011
A deeper understanding of pathophysiology, from the initiation tumors epithelial cells to outcomes associated with it, is imperative test potential interventions for these diseases. However, few models can accomplish this because complexity origin and their transformation. We established an cell original tumor mouse model by conditional KrasG12D activation suppressor gene p53 deletion specifically in whole body using Cytokeratin 19 (CK19) promoter via Cre-ERT mediation. Multiple derived...
This clinical study combined alanyl-glutamine and omega-3 polyunsaturated fatty acids (ω-3 PUFAs) to investigate the effects of parenteral nutrition on postoperative inflammation nutritional status in patients with gastroduodenal perforation provide a basis support for use immunonutrients. Patients perforations who underwent surgery between January 2018 December 2023 were included. From first seventh day, Group A (GA) received conventional fat emulsion (20%), amino (17), glucose (11%)...
Proliferation of vascular smooth muscle cells (SMCs) plays an important role in the development atherosclerosis and restenosis. Extracellular mononucleotides, such as adenosine triphosphate uridine-5′-triphosphate stimulate SMC proliferation. However, effects dinucleotides on proliferation their underlying signaling mechanisms are less well defined. Recently, increasing evidence suggests that dinucleotide, uridine tetraphosphate (Up4A) a regulation cardiovascular function. We have previously...
Somatic mutations in the tuberous sclerosis complex-2 (TSC2) gene are associated with pulmonary lymphangioleiomyomatosis (LAM), a disorder characterized by benign lesions of smooth muscle and/or muscle-like cells lung. However, cellular mechanisms underlying LAM disease largely unknown. Given that TSC2 product tuberin is involved regulation cell growth and proliferation, present study was designed to investigate potential roles cycle. We studied cycle profiles vascular (SMCs) derived from...
ABSTRACT Background & Aims We previously demonstrated the successful use of in vivo CRISPR gene editing to delete 4-hydroxyphenylpyruvate dioxygenase ( HPD ) rescue mice deficient fumarylacetoacetate hydrolase (FAH), a disorder known as hereditary tyrosinemia type 1 (HT1). The goal this study was develop an ex protocol and apply it cell therapy for HT1. Methods isolated hepatocytes from wild-type (C57BL/6) Fah -/- then used optimized electroporation deliver Hpd -targeting CRISPR-Cas9...