MinHyuk Lee

ORCID: 0009-0007-6101-5053
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About
Contact & Profiles
Research Areas
  • Neurobiology and Insect Physiology Research
  • Invertebrate Immune Response Mechanisms
  • Biochemical Analysis and Sensing Techniques
  • Plant Molecular Biology Research
  • Physiological and biochemical adaptations
  • Ion Channels and Receptors
  • Congenital heart defects research
  • Growth Hormone and Insulin-like Growth Factors
  • Glycosylation and Glycoproteins Research
  • Circadian rhythm and melatonin

Korea Brain Research Institute
2023-2025

Samsung Medical Center
2023-2025

Sungkyunkwan University
2023-2025

University of Hertfordshire
1996

Abstract In ephaptic coupling, physically adjacent neurons influence one another’s activity via the electric fields they generate. To date, molecular mechanisms that mediate and modulate coupling’s effects remain poorly understood. Here, we show hyperpolarization-activated cyclic nucleotide-gated (HCN) channel lateralizes potentially mutual inhibition between Drosophila gustatory receptor (GRNs). While sweet-sensing GRNs (sGRNs) engage in suppression of bitter-sensing (bGRNs), HCN expression...

10.1101/2023.08.04.551918 preprint EN cc-by-nc bioRxiv (Cold Spring Harbor Laboratory) 2023-08-08

In ephaptic coupling, physically adjacent neurons influence one another’s activity via the electric fields they generate. To date, molecular mechanisms that mediate and modulate coupling’s effects remain poorly understood. Here, we show hyperpolarization-activated cyclic nucleotide–gated (HCN) channel lateralizes potentially mutual inhibition between Drosophila gustatory receptor (GRNs). While sweet-sensing GRNs (sGRNs) engage in suppression of bitter-sensing (bGRNs), HCN expression sGRNs...

10.1073/pnas.2413134122 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2025-01-17

Establishing transepithelial ion disparities is crucial for sensory functions in animals. In insect organs called sensilla, a potential, known as the sensillum potential (SP), arises through active transport across accessory cells, sensitizing receptor neurons such mechanoreceptors and chemoreceptors. Because multiple are often co-housed share SP, niche-prevalent overstimulation of single can compromise neighboring receptors by depleting SP. However, how depletion prevented to maintain...

10.7554/elife.96602.3 article EN cc-by eLife 2024-07-29

Abstract Establishing transepithelial ion disparities is crucial for sensory functions in animals. In insect organs called sensilla, a potential, known as the sensillum potential (SP), arises through active transport across accessory cells, sensitizing receptor neurons such mechanoreceptors and chemoreceptors. Because multiple are often co-housed share SP, niche-prevalent overstimulation of single can compromise neighboring receptors by depleting SP. However, how depletion prevented to...

10.1101/2024.02.06.579099 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2024-02-06

Establishing transepithelial ion disparities is crucial for sensory functions in animals. In insect organs called sensilla, a potential, known as the sensillum potential (SP), arises through active transport across accessory cells, sensitizing receptor neurons such mechanoreceptors and chemoreceptors. Because multiple are often co-housed share SP, niche-prevalent overstimulation of single can compromise neighboring receptors by depleting SP. However, how depletion prevented to maintain...

10.7554/elife.96602.1 preprint EN 2024-04-05

Establishing transepithelial ion disparities is crucial for sensory functions in animals. In insect organs called sensilla, a potential, known as the sensillum potential (SP), arises through active transport across accessory cells, sensitizing receptor neurons such mechanoreceptors and chemoreceptors. Because multiple are often co-housed share SP, niche-prevalent overstimulation of single can compromise neighboring receptors by depleting SP. However, how depletion prevented to maintain...

10.7554/elife.96602 article EN cc-by eLife 2024-04-05

Establishing transepithelial ion disparities is crucial for sensory functions in animals. In insect organs called sensilla, a potential, known as the sensillum potential (SP), arises through active transport across accessory cells, sensitizing receptor neurons such mechanoreceptors and chemoreceptors. Because multiple are often co-housed share SP, niche-prevalent overstimulation of single can compromise neighboring receptors by depleting SP. However, how depletion prevented to maintain...

10.7554/elife.96602.2 preprint EN 2024-07-12
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