A5091971469- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
University of Guelph
2023-2024
Abstract Background Memory updating is essential for integrating new information into existing representations. However, this process could become maladaptive in conditions like post-traumatic stress disorder (PTSD), when fear memories generalize to neutral contexts. Previously, we have shown that contextual memory malleability rats requires activation of M1 muscarinic acetylcholine receptors the dorsal hippocampus. Here, investigated involvement mechanism transfer other contexts using a...
Memory updating is essential for integrating new information into existing representations. However, this process could become maladaptive in conditions like post-traumatic stress disorder (PTSD), when fear memories generalize to neutral contexts. Previously, we have shown that contextual memory malleability rats requires activation of M1 muscarinic acetylcholine receptors the dorsal hippocampus. Here, investigated involvement mechanism transfer other contexts using a novel paradigm....
Abstract Destabilization of previously consolidated memories places them in a labile state which they are open to modification. However, strongly encoded fear tend be destabilization-resistant and the conditions required destabilize such remain poorly understood. Our lab has shown that exposure salient novel contextual cues during memory reactivation can object location activity at muscarinic cholinergic receptors is critical for this effect. In current study, we similarly targeted memories,...