A5029710140- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Microtubule and mitosis dynamics
- Signaling Pathways in Disease
- Plant Molecular Biology Research
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Telomeres, Telomerase, and Senescence
- Protein Tyrosine Phosphatases
Anhui Agricultural University
2025
Indiana University
2025
Indiana University Bloomington
2024
A programmed developmental switch to G / S endocycles results in tissue growth through an increase cell size. Unscheduled, induced endocycling cells (iECs) promote wound healing but also contribute cancer. Much remains unknown, however, about how these iECs affect growth. Using the D . melanogaster wing disc as model, we find that populations of initially size then subsequently undergo a heterogenous arrest causes severe undergrowth. acquired DNA damage and activated Jun N-terminal kinase...
Abstract The endocycle is a specialized cell cycle during which cells undergo repeated G / S phases to replicate DNA without division, leading large polyploid cells. transition from mitotic an can be triggered by various stresses, results in unscheduled, or induced endocycling (iECs). While iECs beneficial for wound healing, they also detrimental impairing tissue growth promoting cancer. However, the regulation of and its role remain poorly understood. Using Drosophila wing disc as model, we...
Abstract Adenosine deaminases that act on RNA (ADARs) are editing enzymes capable of converting adenosine into inosine at specific sites within double‐stranded (dsRNA), widely distributed across various animal species. Dicer (Dcr), a member the RNase III family and crucial component RNA‐induced silencing complex (RISC), allows ADAR to participate in innate immunity through Dcr‐2 Drosophila . Bombyx mori nucleopolyhedrovirus (BmNPV) is one viruses can cause substantial economic losses...