A5106521011- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Hybrid Renewable Energy Systems
- thermodynamics and calorimetric analyses
- Field-Flow Fractionation Techniques
- RNA and protein synthesis mechanisms
Johannes Gutenberg University Mainz
2024-2025
Abstract RNA methyltransferases (MTases) have recently become increasingly important in drug discovery. Yet, most frequently utilized MTase assays are limited their throughput and hamper this rapidly evolving field of medicinal chemistry. This study developed a microscale thermophoresis (MST)-based split aptamer assay for enzymatic investigations, improving current methodologies by offering non-proprietary, cost-effective, highly sensitive approach. Our findings demonstrate the assay’s...
Abstract RNA methylation is a metabolic process validated for its association with various diseases, and thus, methyltransferases (MTases) have become increasingly important in drug discovery. Yet, most frequently utilized MTase assays are limited their throughput hamper this rapidly evolving field of medicinal chemistry. In study, we describe modular nanomole scale building block system that allowed the identification tailored fluorescent probes to unlock broad selection targets...
Abstract Die Methylierung von RNA ist ein Stoffwechselprozess, der für seine Verbindung zu verschiedenen Krankheiten bekannt geworden ist. Darum gewinnen RNA‐Methyltransferasen (MTasen) in Arzneistoffentwicklung zunehmend an Bedeutung. gängigsten RNA‐MTase‐Assays sind jedoch ihrem Durchsatz begrenzt, was die Entwicklung im dynamischen Forschungsfeld medizinischen Chemie verlangsamt. In dieser Studie präsentieren wir modulares Synthesesystem Nanomolmaßstab, dass Identifizierung...