A5084713384- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Cancer-related gene regulation
- Fungal Infections and Studies
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- PARP inhibition in cancer therapy
- Tuberculosis Research and Epidemiology
- Antifungal resistance and susceptibility
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Nerve injury and regeneration
- Parasitic Diseases Research and Treatment
- Wnt/β-catenin signaling in development and cancer
Westford Academy
2024
Chinese PLA General Hospital
2023-2024
Johns Hopkins University
2011-2015
Johns Hopkins Medicine
2015
Abstract MicroRNAs are emerging to be important epigenetic factors that control axon regeneration. Here, we report microRNA-26a (miR-26a) is a physiological regulator of mammalian regeneration in vivo . We demonstrated endogenous miR-26a acted target specifically glycogen synthase kinase 3 β (GSK3 ) adult mouse sensory neurons vitro and Inhibition impaired Moreover, the regulatory effect was mediated by increased expression GSK3 because downregulation or pharmacological inhibition fully...
Adenomatous polyposis coli (APC) gene mutations have been implicated in familial and sporadic gastrointestinal (GI) cancers. APC are associated with autosomal dominant inheritance of disease humans. Similarly, mice that contain a single mutant encoding protein truncated at residue 716 (ApcΔ716) develop multiple polyps throughout the GI tract as early 4 weeks after birth. Inactivation another tumor suppressor gene, Hypermethylated Cancer 1 (HIC1), often occurs human colon cancers, among...
Aim: The mechanism of RASSF1A in DNA damage repair remains to be further clarified for applying synthetic lethal strategy. Materials & methods: Eight esophageal cancer cell lines, 181 cases dysplasia and 1066 primary squamous carcinoma (ESCC) were employed. Methylation-specific PCR, the CRISPR/Cas9 technique, immunoprecipitation assay a xenograft mouse model used. Results: was methylated 2.21% 11.73% ESCC. also involved through activating Hippo signaling. Loss expression sensitized lines...
Abstract Background The limulus amebocyte lysate (LAL) was widely used in endotoxin detection vitro and the clinical diagnosis of invasive fungal infection. previous data showed that a caffeine collection solution could prevent degranulation during blood procedure, caffeine-derived LAL work both chromogenic test turbidimetric method assays. However, cell pellets collected by aggregates after re-suspension 5 mM CaCl2. No similar phenomenon observed with PBS buffer. purpose this study is to...
Aim: The aim of current study is to explore the epigenetic changes and function KCTD8 in human hepatocellular carcinoma (HCC). Materials & methods: HCC cell lines tissue samples were employed. Methylation specific PCR, flow cytometry, immunoprecipitation xenograft mouse models used. Results: was methylated 44.83% (104/232) its methylation may act as an independent poor prognostic marker. expression regulated by DNA methylation. suppressed growth both vitro vivo via inhibiting PI3K/AKT...