A5047689869- Hidradenitis Suppurativa and Treatments
- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- Colorectal and Anal Carcinomas
- Cutaneous lymphoproliferative disorders research
- Colorectal Cancer Treatments and Studies
- Angiogenesis and VEGF in Cancer
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Autoimmune and Inflammatory Disorders
- Chemotherapy-related skin toxicity
- Eosinophilic Disorders and Syndromes
- Autoimmune Bullous Skin Diseases
- PARP inhibition in cancer therapy
- Lymphoma Diagnosis and Treatment
- Skin Diseases and Diabetes
- Cancer and Skin Lesions
- Tumors and Oncological Cases
- Pancreatic and Hepatic Oncology Research
- Facial Nerve Paralysis Treatment and Research
- Vascular Malformations and Hemangiomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Dermatologic Treatments and Research
- Wound Healing and Treatments
- Immunotherapy and Immune Responses
Thomas Jefferson University
2016-2025
Thomas Jefferson University Hospital
2015-2024
Philadelphia University
2024
Harvard University
2024
Target (United States)
2008-2023
Advanced Dermatology
2019
Henry Ford Health System
2015
National Cancer Institute
2005-2014
Saint Louis University
2014
Henry Ford Hospital
2014
Ixabepilone is an epothilone B analog that binds to microtubules and results in microtubule stabilization mitotic arrest. was evaluated for efficacy safety a phase II clinical trial women with metastatic breast cancer.Patients were eligible if they had not previously received treatment taxane measurable cancer. administered at 6 mg/m(2)/d intravenously days 1 through 5 every 3 weeks until unacceptable toxicity or disease progression. Patients underwent pretreatment post-treatment tumor...
Foundation models pretrained on diverse data at scale have demonstrated extraordinary capabilities in a wide range of vision and language tasks. When such are deployed real world environments, they inevitably interface with other entities agents. For example, often used to interact human beings through dialogue, visual perception autonomously navigate neighborhood streets. In response these developments, new paradigms emerging for training foundation agents perform long-term reasoning. These...
Purpose: To determine the maximum-tolerated dose (MTD) and toxicity profile of novel anticancer agent, 2-methoxyestradiol (2ME2) administered orally, in patients with solid tumors. Patients Methods: Twenty refractory tumors were enrolled. 2ME2 was given orally starting at 400 mg bid escalation until 3000 bid. Tumor biopsies taken before after drug to assess for microvessel density by CD 31 cell proliferation Ki67 immunohistochemistry. Serial plasma samples collected up 50 hours first single...
Abstract Purpose: To identify biomarkers and gene expression profile signatures to distinguish patients with partial response (PR) from those stable disease (SD) progressive (PD). Experimental Design: Twenty inflammatory breast cancer one patient locally advanced received cycle of bevacizumab followed by six cycles plus docetaxel-doxorubicin before surgery. Baseline angiogenic/tumor markers were examined immunohistochemistry profiles measured Agilent Whole Human Genome arrays. All assessed...
Background: Hidradenitis suppurativa (HS) has been previously associated with greater rates of major adverse cardiac events (MACEs) compared to the general population. This study aims better elucidate association between HS, MACEs, and other cardiovascular diseases. Methods: We utilized TriNetX, a global database electronic health records, conduct retrospective cohort study. HS patients were matched on demographic disease risk factors both healthy psoriasis groups as controls. Results: After...
Cutaneous cytomegalovirus infection is a rare but serious complication in solid organ transplant recipients. We present 47-year-old male kidney recipient with chronic, nonhealing right lower extremity ulcer. Initial biopsies revealed septic vasculopathy, leading to treatment sodium thiosulfate and antibiotics for suspected calciphylaxis. Despite regular wound care, the ulcer continued worsen. After completing 6 months of prophylaxis, surveillance viral levels remained undetectable,...
Purpose: Noninvasive markers of anti-vascular endothelial growth factor (VEGF) therapy are needed. Soluble vascular cell adhesion molecule (sVCAM-1), soluble VEGF receptor-2 (sVEGFR-2), and plasma levels were assessed as potential biomarkers with bevacizumab. Tumor samples evaluated for VEGFR-2 mutations before after bevacizumab.Experimental Design: Twenty-one patients breast cancer underwent neoadjuvant treatment bevacizumab 1 cycle followed by 6 cycles bevacizumab, chemotherapy,...
Abstract Purpose: To delineate gene expression patterns and profile changes in metastatic tumor biopsies at baseline 1 month after treatment with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib patients breast cancer. Experimental Design: Patients were treated 150 mg of oral daily. Gene profiles measured Affymetrix U133A GeneChip immunohistochemistry was used to validate microarray findings. Results: Estrogen (ER) status by is nearly coincided two major...
Both text and video data are abundant on the internet support large-scale self-supervised learning through next token or frame prediction. However, they have not been equally leveraged: language models had significant real-world impact, whereas generation has remained largely limited to media entertainment. Yet captures important information about physical world that is difficult express in language. To address this gap, we discuss an under-appreciated opportunity extend solve tasks real...
Bilayered suture repairs have become the standard of care in dermatologic surgery. However, benefit superficial sutures for fine epidermal alignment on high-tension areas remains unclear.To compare overall cosmetic outcome traditional with adhesive strips layered back.A total 10 patients underwent elliptical excision back followed by subcutaneous closure 4-0 polyglactin 910 buried sutures. Each half wound was then randomized to either polypropylene running or 1/4″ Steri-Strip films...
Hidradenitis suppurativa (HS) is a painful chronic skin condition of apocrine gland regions. This retrospective cohort study aimed to assess the impact hormonal contraception type on HS disease control in adult women. In total, 160 patients were included, with majority identifying as Black or African American (73.1%). Multivariate logistic regression showed that oestrogen-progesterone users 3.14 times more likely experience stable improved than progesterone-only (adjusted odds ratio 3.14,...
Cancers arising in pancreas, lung, liver and stomach are difficult to treat successfully. Wanting understand the basis for such intractability, we previously performed comparative analyses of publicly available gene expression data from tumor biopsies. Expression many cell adhesion genes correlated significantly with intractability cancers, our surrogate being SEER five-year survivals patients disseminated tumors. To model resistance mediated by adhesion, evaluated HCT 116 cells grown two...
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Generative models trained at scale can now produce text, video, and more recently, scientific data such as crystal structures. In applications of generative approaches to materials science, in particular structures, the guidance from domain expert form high-level instructions be essential for an automated system output candidate crystals that are viable downstream research. this work, we formulate end-to-end language-to-structure generation a multi-objective optimization problem, propose...
B-cell lymphoblastic lymphoma (B-LBL) is a malignant neoplasm of immature B cells that accounts for only 10% all cases lymphoma. Most commonly, B-LBL presents as bony lesions, but in rare cases, the disease manifests cutaneously. We present case simultaneous cutaneous and systemic presentation an otherwise healthy 28-year-old man which infiltrate stained positive CD79a, Tdt, CD10, CD20. A diagnosis was made, work-up revealed widespread involvement skin, bone, lymph nodes. Review currently...