A5082094976- Natural Language Processing Techniques
- Topic Modeling
- Advanced Text Analysis Techniques
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- EEG and Brain-Computer Interfaces
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Bioactive natural compounds
- Composite Structure Analysis and Optimization
- Authorship Attribution and Profiling
- Astronomical Observations and Instrumentation
- Metabolomics and Mass Spectrometry Studies
- Space Satellite Systems and Control
- Power Line Inspection Robots
- Soft Robotics and Applications
Shanghai Ninth People's Hospital
2018-2024
Shanghai Jiao Tong University
2015-2024
Yale University
2022
Meta (Israel)
2022
Columbia University
2022
Second Military Medical University
2017-2021
Eastern Hepatobiliary Surgery Hospital
2017-2021
Target (United States)
2020
Health Affairs
2020
Dalian University of Technology
2018-2019
Abstract Hepatocellular carcinoma (HCC), a common liver malignancy worldwide, has high morbidity and mortality. β-Thujaplicin, tropolone derivative, been used in some health-care products clinical adjuvant drugs, but its use for HCC is unknown. In this study, we found that β-Thujaplicin inhibits the growth of cells, not normal with nanomolar potency. Mechanistically, could induce autophagy, as judged by western blot, confocal microscopy, transmission electron microscopy. Further using...
Abstract Existing table question answering datasets contain abundant factual questions that primarily evaluate a QA system’s comprehension of query and tabular data. However, restricted by their short-form answers, these fail to include question–answer interactions represent more advanced naturally occurring information needs: ask for reasoning integration pieces retrieved from structured knowledge source. To complement the existing reveal challenging nature table-based task, we introduce...
UFMylation is a ubiquitin-like modification which attaches the ubiquitin-fold modifier 1 to target proteins. To date, only few targets have been identified. In current study, we demonstrated that P4HB new protein for and it can be UFMylated at three lysine residues in form of mono-UFMylation. has oxidoreductase, chaperone isomerase effects. It presents endoplasmic reticulum, mitochondria cytosol. Next, generated stable HepG2 cell line, hepatocellular cells, with defective UFMylation. Our...
Yusen Zhang, Ansong Ni, Ziming Mao, Chen Henry Wu, Chenguang Zhu, Budhaditya Deb, Ahmed Awadallah, Dragomir Radev, Rui Zhang. Proceedings of the 60th Annual Meeting Association for Computational Linguistics (Volume 1: Long Papers). 2022.
Ziming Mao, Chen Henry Wu, Ansong Ni, Yusen Zhang, Rui Tao Yu, Budhaditya Deb, Chenguang Zhu, Ahmed Awadallah, Dragomir Radev. Proceedings of the 60th Annual Meeting Association for Computational Linguistics (Volume 1: Long Papers). 2022.
Macrophage activation is an essential component of systemic chronic inflammation and inflammatory diseases. Emerging evidence implicates miR-185-5p in However, the regulatory role macrophage pro-inflammatory has not been studied previously. Here, we identified that was one top genes effectively downregulated two miRNA expression datasets from GEO. Under LPS stress, overexpression reduced cytokine expression, suppressed phagocytosis RAW264.7 macrophage. inhibitors augmented effects...
Non-alcoholic fatty liver disease (NAFLD) is the most common characterized by lipid accumulation and endoplasmic reticulum (ER) stress, while effective therapies targeting specific characteristics of NAFLD are limited. Ufmylation a newly found post-translational modification process that involves attachment Ubiquitin-fold modifier 1 (UFM1) protein to its substrates via ufmylation system. regulates ER stress modifying UFM1 binding (UFBP1), suggesting potential role for in pathogenesis....
Prior work employing deep neural networks (DNNs) with explainable techniques has identified human visual cortical selective representation to specific categories. However, constructing high-performing encoding models that accurately capture brain responses coexisting multi-semantics remains elusive. Here, we used CLIP combined Dissection establish a multi-semantic mapping framework (CLIP-MSM) for hypothesis-free analysis in high-level cortex. First, utilize construct voxel-wise predicting...
Pancreatic adenocarcinoma (PAC) is one of the most fatal cancers due to its high degree malignancy, increasing incidence, mortality, and unsatisfactory treatment efficacy. Evidence has suggested that numerous microRNAs (miRNAs), including miR-126 miR-34a, have potent tumor-suppressing effects on PAC, implicating a possible application miRNA in tumor therapy. However, therapeutic effect single pancreatic cancer limited.We simultaneously delivered miR-34a into PAC cells by carcinoembryonic...
Transformer-based models have achieved state-of-the-art performance on short-input summarization. However, they still struggle with summarizing longer text. In this paper, we present DYLE, a novel dynamic latent extraction approach for abstractive long-input DYLE jointly trains an extractor and generator treats the extracted text snippets as variable, allowing snippet-level attention weights during decoding. To provide adequate supervision, propose simple yet effective heuristics oracle well...
Non-alcoholic fatty liver disease (NAFLD) has been considered to be one of the most common chronic diseases. However, no validated pharmacological therapies have officially proved in clinic due its complex pathogenesis. The purpose this study was examine protective effects Corilagin (referred Cori) against NAFLD mice under a high fat diet (HFD) condition. Mice were fed either normal control (NCD) or HFD with without Cori (5 10 mg/kg body weight) for 15 weeks. In our results, treatment...
Xiangru Tang, Alexander Fabbri, Haoran Li, Ziming Mao, Griffin Adams, Borui Wang, Asli Celikyilmaz, Yashar Mehdad, Dragomir Radev. Proceedings of the 2022 Conference North American Chapter Association for Computational Linguistics: Human Language Technologies. 2022.
Text summarization helps readers capture salient information from documents, news, interviews, and meetings. However, most state-of-the-art pretrained language models (LM) are unable to efficiently process long text for many tasks. In this paper, we propose Summ$^N$, a simple, flexible, effective multi-stage framework input texts that longer than the maximum context length of typical LMs. Summ$^N$ first splits data samples generates coarse summary in multiple stages then produces final...
Hepatocellular carcinoma (HCC) is one of the most common subtypes malignant liver tumors, characterized by high morbidity and mortality. Due to its poor diagnosis strategy inefficient clinical intervention, HCC has brought terrible life experiences for patients worldwide. Finding novel curative agents urgently needed. In current study, we hypothesized that lncRNA PANTR1 participates in initiation or progression. Our study found was upregulated tumor tissues abundantly expressed cell lines....
Abstract The interaction between circRNAs and atherosclerosis has been extensively studied. However, more novel need to be explored help establish a perfect regulatory network. In the present research, hsa_circ_0000345 was demonstrated regulate cellular development of oxygenized low‐density lipoprotein (ox‐LDL)‐treated aortic smooth muscle cells (ASMCs), which closely related occurrence progress atherosclerosis. Ox‐LDL exposure remarkably decreased expression in ASMCs. Transfection‐induced...
In recent years, space robot on-orbit service has become a research hotspot in many countries. Aiming at the task of capturing non-cooperative targets for robot, dual loop control method consisting reinforcement learning and PD is proposed this paper, which used to attitude platform motion manipulator arm. Firstly, coupled dynamic model including base arm established. Then, system designed movement platform. inner loop, controller by combining fuzzy theory end outer stabilized control....