A5060118225- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Intraperitoneal and Appendiceal Malignancies
- Genetic factors in colorectal cancer
- Family Support in Illness
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- DNA Repair Mechanisms
National Health Laboratory Service
2024
University of the Witwatersrand
2024
Universidade Federal do Ceará
2019
Abstract Purpose Genetically predisposed breast cancer (BC) patients represent a minor but clinically meaningful subgroup of the disease, with 25% all cases associated actionable variants in BRCA1/2 . Diagnostic implementation next-generation sequencing (NGS) resulted rare identification BC double heterozygosity for deleterious genes partaking homologous recombination repair DNA. As clinical heterogeneity poses challenges genetic counseling, this study focused on occurrence and relevance...
Aim Breast cancer is the most prevalent in South African females, making up 27.1% of all histologically diagnosed cancers 2020. Although genetic technology and awareness counselling have improved, services Africa remain largely inaccessible. Clinical are only formally available four provinces few outreach programmes exist for small towns cities. Until 2019, were unavailable North West province; however, since then, counsellors from National Health Laboratory Service University Witwatersrand...
e12013 Background: It is estimated that 50,000 new cases of BC will be diagnosed in Brazil 2011. Currently, TNM staging the most widely used prognostic factor. The classification different histological subtypes may further improve survival estimation and help guiding on selection best therapeutic approach. Due to lack epidemiological data Brazil, we have carried out this study. Methods: main objective study was evaluate 3 year disease-free (DFS) overall (OS) rates women with treated curative...