A5094171925- Mitochondrial Function and Pathology
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Genetic Neurodegenerative Diseases
- Autophagy in Disease and Therapy
- Monoclonal and Polyclonal Antibodies Research
- Phagocytosis and Immune Regulation
- Chronic Lymphocytic Leukemia Research
- Pancreatitis Pathology and Treatment
Queen Mary University of London
2024
William Harvey Research Institute
2024
Barts Health NHS Trust
2024
University College London
2024
National Hospital for Neurology and Neurosurgery
2024
Abstract The TAM tyrosine kinases, Axl and MerTK, play an important role in rheumatoid arthritis (RA). Here, using a unique synovial tissue bioresource of patients with RA matched for disease stage treatment exposure, we assessed how MerTK relate to histopathology activity, their topographical expression longitudinal modulation by targeted treatments. We show that treatment-naive patients, high AXL levels are associated pauci-immune histology low activity inversely correlate the...
<h3>Background:</h3> Despite the availability of effective treatments, up to 10-20% patients with Rheumatoid Arthritis (RA) do not respond multiple targeted medications and can be classified as multi-drug resistant (MDR). MDR-RA has been linked both extrinsic factors, such comorbidities non-compliance and, intrinsic factors related molecular pathology diseased tissue. For example, recently, a stromal synovial signature associated resistance. However, role immune cells pathways in mediating...
Abstract Efficient long-range axonal transport is essential for maintaining neuronal function, and perturbations in this process underlie severe neurological diseases. We have previously demonstrated that signalling endosomes are transported vivo at comparable speeds across motor neurons (MNs) innervating different hindlimb muscles, as well between forelimb peripheral nerves. In contrast, faster MNs compared to sensory the same muscle. Found periodically myelin sheath, Nodes of Ranvier (NoR)...