A5081522516- Sepsis Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory Support and Mechanisms
- Safe Handling of Antineoplastic Drugs
- Emergency and Acute Care Studies
- Nosocomial Infections in ICU
- Liver Disease and Transplantation
- Intensive Care Unit Cognitive Disorders
- Inflammatory Myopathies and Dermatomyositis
- Cancer Treatment and Pharmacology
- Asthma and respiratory diseases
- Eosinophilic Disorders and Syndromes
- Machine Learning in Healthcare
- Pneumonia and Respiratory Infections
- Cancer Immunotherapy and Biomarkers
- Blood disorders and treatments
- Inhalation and Respiratory Drug Delivery
- Systemic Sclerosis and Related Diseases
- Hematopoietic Stem Cell Transplantation
- Cardiovascular Issues in Pregnancy
- Clinical Reasoning and Diagnostic Skills
Washington University in St. Louis
2014-2025
Barnes-Jewish Hospital
2022-2023
Ninewells Hospital
2023
Oregon Health & Science University
2023
Milliken & Company (United States)
2021
Warrington and Halton Teaching Hospitals NHS Foundation Trust
2016
Northwestern University
2010-2011
Prisma Health
2008
University Medical Center
2008
University Hospital and Clinics
2008
Checklists may reduce errors of omission for critically ill patients.To determine whether prompting to use a checklist improves process care and clinical outcomes.We conducted cohort study in the medical intensive unit (MICU) tertiary university hospital. Patients admitted either two independent MICU teams were included. Intervention team physicians prompted address six parameters from daily rounding if overlooked during morning work rounds. The second (control) used identical without...
Abstract Introduction Septic shock is a major cause of morbidity and mortality throughout the world. Unfortunately, optimal fluid management septic unknown currently empirical. Methods A retrospective analysis was performed at Barnes-Jewish Hospital (St. Louis, Missouri). Consecutive patients (n = 325) hospitalized with who had echocardiographic examinations within 24 hours onset were enrolled. Results total 163 (50.2%) died during hospitalization. Non-survivors significantly larger positive...
Objective A post-hoc analysis of the INCREASE trial and its open-label extension (OLE) was performed to evaluate whether inhaled treprostinil has a long-term survival benefit in patients with pulmonary hypertension associated interstitial lung disease (PH-ILD). Methods Two different models were employed; inverse probability censoring weighting (IPCW) rank-preserving structural failure time (RPSFT) both allow construction pseudo-placebo group, thereby allowing for evaluation PH-ILD receiving...
A long-term trial showed that the oral prostacyclin (PGl2) receptor (IP) agonist, selexipag, delayed disease progression in patients with pulmonary arterial hypertension (PAH). Transition to selexipag treated more burdensome inhaled therapies target pathway may be considered by and physicians. The Phase 3b, prospective, open-label TRANSIT-1 (Tolerability Safety of From Inhaled Treprostinil Oral Selexipag Patients With Pulmonary Arterial Hypertension) study evaluated safety tolerability...
Background: Serotonin reuptake inhibitor (SRI) antidepressants have known antiplatelet properties. Patients with hematologic malignancies (HMs) are at an increased risk of bleeding complications due to their malignancy and treatment-induced thrombocytopenia. Objective: The purpose this study was evaluate the clinically significant (CSB) in patients HM thrombocytopenia who prescribed SRIs. Methods: This retrospective cohort included adult admitted hospital were stratified into SRI-exposed...
Background Chimeric antigen receptor (CAR) T cells are a leading immunotherapy for refractory B-cell malignancies, but their impact is constrained by toxicity and incomplete long-term efficacy. Daily (circadian) rhythms in immune function may offer lever to boost therapeutic success. Studies suggest that time of day influences immune-based therapies, including vaccines, hematopoietic stem cell transplantation, checkpoint inhibitors cancer. However, the clinical relevance biological CAR-T...
Takotsubo cardiomyopathy mimics acute myocardial infarction but is a separate clinical entity characterized by distinct wall motion abnormalities in the absence of obstructive coronary lesions. The prevalence this condition relatively uncommon yet has gained increasing recognition recent years. It rarely been associated with use dobutamine infusion during cardiac stress testing. We present detail two cases dobutamine‐induced from our case series, one 2002 and other 2008. While both display...
Patients hospitalized outside the intensive care unit (ICU) frequently experience clinical deterioration. Little has been done to describe landscape of deterioration among inpatients with cancer. We aimed frequency patients cancer on wards at a major academic hospital and identify independent risk factors for these patients.This was retrospective cohort study 1,300-bed urban 138-bed inpatient center. included consecutive admissions oncology between January 1, 2014, June 30, 2017. defined as...
To describe the infectious complications and interleukin-6 trajectories in mechanically ventilated patients with coronavirus disease 2019.Retrospective cohort study.ICUs at Washington University-Barnes Jewish Hospital St. Louis, MO.All consecutive admitted to medical ICU requiring mechanical ventilation from March 12, 2020, April 21, were included.Tocilizumab, an receptor blocker, was prescribed discretion of treating physicians a clinical picture compatible cytokine release syndrome.All...
Abstract Stenotrophomonas maltophilia (SM) bloodstream infections (BSIs) contribute to significant mortality in hematologic malignancy (HM) and hematopoietic stem cell transplantation (HSCT) patients. A risk score predict SM BSI could reduce time appropriate antimicrobial therapy (TTAT) improve patient outcomes. single center cohort study of hospitalized adults with HM/HSCT was conducted. Patients had ≥ 1 blood culture a Gram-negative (GN) organism. StenoSCORE calculated for each patient....
PURPOSE To elicit end-user and stakeholder perceptions regarding design implementation of an inpatient clinical deterioration early warning system (EWS) for oncology patients to better fit routine practices enhance impact. METHODS In explanatory-sequential mixed-methods study, we evaluated a stakeholder-informed (OncEWS) using surveys semistructured interviews. Stakeholders were physicians, advanced practice providers (APPs), nurses. For qualitative data, used grounded theory thematic...
Background: Macrolide-based treatment has been associated with survival benefit in patients hospitalized community-acquired pneumonia (CAP). However, the influence of macrolide therapy all pneumonia, including healthcare-associated (HCAP), is unclear. Methods: Analysis a retrospective single-center cohort. Results: Community-acquired was present 220 (22.5%) admitted through emergency department Barnes-Jewish Hospital, and HCAP 757. administered to 411 (42.1%). These were more likely have CAP...
OBJECTIVES: To report the epidemiology, treatments, and outcomes of adult patients admitted to ICU after cytokine release syndrome or immune effector cell-associated neurotoxicity syndrome. DESIGN: Retrospective cohort study SETTING: Nine centers across U.S. part chimeric antigen receptor-ICU initiative. PATIENTS: Adult treated with receptor T-cell therapy who required admission between November 2017 May 2019. INTERVENTIONS: Demographics, toxicities, specific interventions, were collected....