A5028045271- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Diabetes and associated disorders
- CRISPR and Genetic Engineering
- Glycosylation and Glycoproteins Research
- Lymphoma Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Rheumatoid Arthritis Research and Therapies
- Infectious Encephalopathies and Encephalitis
- Advanced biosensing and bioanalysis techniques
- HER2/EGFR in Cancer Research
- Prostate Cancer Treatment and Research
- Single-cell and spatial transcriptomics
- Celiac Disease Research and Management
Institute of Molecular Biotechnology
2024
Garvan Institute of Medical Research
2024
Radboud University Nijmegen
2017-2019
Radboud University Medical Center
2017-2019
HAN University of Applied Sciences
2019
Radboud Institute for Molecular Life Sciences
2017
University Medical Center Utrecht
2011
Pooled genetic screening with CRISPR–Cas9 has enabled genome-wide, high-resolution mapping of genes to phenotypes, but assessing the effect a given perturbation requires evaluation each single guide RNA (sgRNA) in hundreds cells counter stochastic drift and obtain robust results. However, resolution is limited complex, heterogeneous models, such as organoids or tumors transplanted into mice, because achieving sufficient representation impractical scaling. This due bottleneck effects...
It is unclear whether Hashimoto's thyroiditis and Graves' disease (often referred to as autoimmune thyroid disease, AITD) cluster the same extent with other disorders.We assessed adrenal, β-cell, celiac gastric antibodies in a cohort of 523 adult patients 359 compared their clustering.Adrenal autoimmunity associated more often (9.0%) than (3.3%, P=0.001). β-cell was seen frequently (25.4%) (15.6%, P=0.001) patients. We found low prevalences (1.2% for 1.2% disease). Celiac were not...
Abstract Background : Mitochondrial disease (MD) is a group of disorders caused by dysfunctional mitochondria, the organelles that generate energy for cell. Malnutrition in patients with MD may lead to increased mitochondrial dysfunction, which enhance already existing symptoms. The aim this study was investigate whether have an insufficient or unbalanced food intake and establish nutrients product groups are particularly compromised patient group. Methods In observational, cross‐sectional,...
Abstract Objective Multiple lines of evidence suggest that sex hormones may play a role in the pathogenesis or clinical expression rheumatoid arthritis (RA). Studies on effects exogenous estrogens RA patients have yielded contradictory results. We undertook this study to determine selective estrogen receptor α (ERα) agonist Org 37663 with RA, terms both its estrogenic and ability ameliorate disease activity. Methods A 10‐week, multicenter, randomized, double‐blind, placebo‐controlled,...
Abstract Localised prostate cancers (PCa) are heterogeneous and multifocal, with diverse outcomes. Current prognostic methods epithelium-centric, overlooking the complex cellular landscape within tumour microenvironment (TME), which remains incompletely characterised. We performed a comprehensive analysis of cancerous adjacent-benign cores from 24 patients hormone therapy-naïve localised PCa using single-cell RNA-sequencing. By integrating copy number variation transcriptional signatures, we...