About
Contact & Profiles
A5073282386
Research Areas
- RNA regulation and disease
- RNA Research and Splicing
- Alzheimer's disease research and treatments
Boston University
2021
Significance Phase separation of proteins is increasingly thought to play a fundamental role in biological processes. Recent studies show that tau protein phase separates, but the significance unknown since artificial crowding agents are typically used and resulting not toxic. We now demonstrate TIA1 potentiates RNA-mediated tau, thereby enabling process occurs at physiological concentrations also directs formation biologically active, highly neurotoxic oligomeric tau. Coordinated...
10.1073/pnas.2014188118
article
EN
cc-by-nc-nd
Proceedings of the National Academy of Sciences
2021-02-22
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