A5015172766- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- Viral gastroenteritis research and epidemiology
- Viral-associated cancers and disorders
- Biochemical and Molecular Research
- RNA regulation and disease
- Cleft Lip and Palate Research
- Reconstructive Surgery and Microvascular Techniques
- Dental Implant Techniques and Outcomes
- Virus-based gene therapy research
Amsterdam University Medical Centers
2021-2024
University of Amsterdam
1973-2024
Utrecht University
2020
Several recent studies indicate that mutations in the human immunodeficiency virus type 1 (HIV-1) 3'polypurine tract (3'PPT) motif can reduce sensitivity to integrase inhibitor dolutegravir (DTG). Using an vivo systematic evolution of ligands by exponential enrichment (SELEX) approach, we discovered multiple different this viral RNA element confer DTG resistance, suggesting inactivation critical reverse transcription causes resistance. An analysis DNA products formed upon infection these...