A5009647425- Catalytic C–H Functionalization Methods
- Organoboron and organosilicon chemistry
- Radical Photochemical Reactions
- Cyclopropane Reaction Mechanisms
- Catalytic Cross-Coupling Reactions
- Click Chemistry and Applications
- Catalytic Alkyne Reactions
- Synthetic Organic Chemistry Methods
- Biochemical and Molecular Research
- Synthesis and biological activity
- Sulfur-Based Synthesis Techniques
University of Bristol
2022-2023
East China Normal University
2019-2021
Abstract Site‐selective transition‐metal‐catalyzed mono‐deboronative cross‐couplings of 1,2‐bis‐boronic esters are valuable methods for the synthesis functionalized organoboron compounds. However, such limited to reaction sterically less hindered primary boronic ester. Herein, we report a nickel/photoredox‐catalyzed arylation that is selective coupling more secondary/tertiary position. This achieved by taking advantage 1,2‐boron shift β‐boryl radicals thermodynamically favored radicals,...
Borylations of inert carbon-hydrogen bonds are highly useful for transforming feedstock chemicals into versatile organoboron reagents. Catalysis these reactions has historically relied on precious-metal complexes, which promote dehydrogenative borylations with diboron reagents under oxidant-free conditions. Recently, photoinduced radical-mediated involving hydrogen atom transfer pathways have emerged as attractive alternatives because they provide complimentary regioselectivities and proceed...
The classic transformations of N-sulfonyl-1,2,3-triazoles were processed via nitrogen anion (hydrolysis, etc.) and carbene intermediates, no efficient examples radical intermediates developed. Here, we reported a catalyst-free chain transformation to access an intermolecular oxidative C(sp3)–H coupling yield N2-selective products in air without any catalysts.
Abstract Site‐selective transition‐metal‐catalyzed mono‐deboronative cross‐couplings of 1,2‐bis‐boronic esters are valuable methods for the synthesis functionalized organoboron compounds. However, such limited to reaction sterically less hindered primary boronic ester. Herein, we report a nickel/photoredox‐catalyzed arylation that is selective coupling more secondary/tertiary position. This achieved by taking advantage 1,2‐boron shift β‐boryl radicals thermodynamically favored radicals,...
A Pd-catalyzed multicomponent reaction was developed by trapping oxomium ylide with nitrosobenzene via Pd-promoted umpolung chemistry. The Pd catalyst plays two important roles: diazo compound decomposed and Lewis acid for the activation of nitrosobenzene. This strategy provides some insight into a new way discovery methodology to construct complex molecules. method also rapid access series O-(2-oxy) hydroxylamine derivatives, which exhibit good anticancer activity in osteosarcoma cells.
A green and highly efficient one-pot method for α-diaryl-β-alkynol derivatives in water at room temperature was developed using the cocatalysis of a Lewis acid meso-tetraphenylporphyrin iron(III) chloride (FeTPPCl). The unprecedented transformation promoted by modulation charge properties propargylic carbocation chemistry use an situ-generated oxonium ylide as matching nucleophile. reaction performed with step-economic manipulation good to excellent yields broad substrate scope. Water also...