A5103103990- Gut microbiota and health
- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Gastrointestinal motility and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Receptor Mechanisms and Signaling
- Sphingolipid Metabolism and Signaling
- Pharmacological Effects of Natural Compounds
- Tryptophan and brain disorders
Capital Medical University
2023-2025
Gut microbiome dysbiosis has been widely implicated in cognitive impairment, but the identity of specific bacterial taxa and mechanisms are not fully elucidated. Brain glucose hypometabolism coincides with decline. This study explored link among cognition, gut microbiota uptake based on fecal transplantation from mild impairment individuals (MCI-FMT) investigated whether similar were involved 27-hydroxycholesterol (27-OHC)-induced Our results showed that MCI-FMT mice exhibited learning...
Background/Objectives: Alterations of oxysterols and gut microbiota have been recognized as indicators affecting mild cognitive impairment (MCI) sarcopenia, respectively, whereas their association with co-dysfunction has not investigated. Methods: In this study, a total 1035 individuals were divided into Control (n = 264), MCI 435), possible sarcopenia (MPS, n 336) groups. Cognition muscle indexes, serum oxysterols, measured. Spearman's rank coefficients calculated to determine correlations....
Brain glucose hypometabolism is a significant manifestation of Alzheimer's disease (AD). 27-hydroxycholesterol (27-OHC) and the gut microbiota have been recognized as factors possibly influencing pathogenesis AD. This study aimed to investigate link between 27-OHC, microbiota, brain uptake in Here, 6-month-old male C57BL/6 J mice were treated with sterile water or antibiotic cocktails, without 27-OHC and/or synthetic enzyme CYP27A1 inhibitor anastrozole (ANS). The levels, memory ability...
Oxysterols, as metabolites of cholesterol, play a key role in cholesterol homeostasis, autophagosome formation, and regulation immune responses. Disorders oxysterol metabolism are closely related to the pathogenesis neurodegenerative diseases. To systematically investigate profound molecular regulatory mechanisms diseases, it is necessary quantify oxysterols their central peripheral biospecimens simultaneously accurately. However, there lot unsolved problems with existing methods, such...