Federica Di Maggio
A5018210056- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Gestational Diabetes Research and Management
- Systemic Lupus Erythematosus Research
- Cardiomyopathy and Myosin Studies
- Hydraulic Fracturing and Reservoir Analysis
- Gastric Cancer Management and Outcomes
- Hydrocarbon exploration and reservoir analysis
- Neonatal Respiratory Health Research
- Rheumatoid Arthritis Research and Therapies
- Seismic Imaging and Inversion Techniques
- Genetic factors in colorectal cancer
- NMR spectroscopy and applications
- Cystic Fibrosis Research Advances
- Satellite Communication Systems
- Epigenetics and DNA Methylation
- Adrenal and Paraganglionic Tumors
Ceinge Biotecnologie Avanzate (Italy)
2019-2025
University of Naples Federico II
1984-2025
Imperial College London
2024
Eni (Italy)
2018-2021
Weill Cornell Medicine
2020
Cornell University
2020
University of Cagliari
2015
University of Rome Tor Vergata
2014
Center for Advanced Studies Research and Development in Sardinia
1997-2002
Abstract Purpose: The multi-kinase inhibitor (mKi) regorafenib has demonstrated efficacy in chemorefractory patients with metastatic colorectal cancer (mCRC). However, lack of predictive biomarkers and concerns over significant toxicities hamper the use clinical practice. Experimental Design: Serial liquid biopsies were obtained at baseline monthly until disease progression mCRC treated a phase II trial (PROSPECT-R n = 40; NCT03010722) multicentric validation cohort (n 241). Tissue collected...
The purpose of this study was to assess the value genetic testing in addition a comprehensive clinical evaluation, as part diagnostic work-up elite and/or amateur Italian athletes referred for suspicion inherited cardiac disease, following pre-participation screening programme.Between January 2009-December 2018, 5892 consecutive participants, 61 were investigated: 30 and 31 athletes. Elite selected, on basis from two experienced centres cardiovascular evaluation. Furthermore, investigated...
The future generation of High Throughput Satellite (HTS) for broadband distributed user access is strictly connected to the use Ka-band and beyond frequencies. This related requirement reaching so-called "terabit connectivity" support increasing bit rate requirements. In order reach terabit connectivity target, an important breakthrough needed in terms bandwidth availability, hence "beyond Ka-band" frequencies mandatory dispose a larger spectrum. As matter fact HTS are limited; hence, very...
Breast cancer is the most common neoplasia in females worldwide, about 10% being hereditary/familial and due to DNA variants cancer-predisposing genes, such as highly penetrant BRCA1/BRCA2 genes. However, their explain up 25% of suspected cases. The availability NGS methodologies has prompted research this field. With aim improve diagnostic sensitivity molecular testing, a custom designed panel 44 including also non-coding regions 5' 3' UTR regions, was set up. Here, are reported results...
The purpose of this paper is to present a clinical and laboratory study family, in which 12-year-old boy was examined assess his health status before starting competitive sports. A variety instrumental tests were used evaluate the heart its functions. Using Sanger sequencing (SS), we sequenced six related genes verify suspected arrhythmogenic right ventricular cardiomyopathy (ARVC) hypothesized at cardiac assessment and, subsequently, by next-generation (NGS)-based multi-gene panel for more...
Pituitary adenomas (PAs), usually benign lesions, can sometimes present with "aggressive" features (rapid growth, local invasiveness, scarce response to conventional treatments). Despite the fact that a few genetic alterations have been associated this clinical behavior, role of epigenetic modifications, mainly methylation and miRNAs activity, is now opening new frontiers in field. We evaluated profile 21 PA (11 GH-omas, 10 nonfunctioning tumors-NFPAs) samples from TNS surgery 5 normal...
Breast implant-associated lymphoma (BIA-ALCL) has recently been recognized as an independent peripheral T-cell (PTCL) entity. In this study, we generated the first BIA-ALCL patient-derived tumor xenograft (PDTX) model (IL89) and a matching continuous cell line (IL89_CL#3488) to discover potential vulnerabilities druggable targets. We characterized IL89 IL89_CL#3488, both phenotypically genotypically, demonstrated that they closely resemble human primary lymphoma. The content underwent...
Alzheimer’s disease (AD) is a fatal neurodegenerative disorder caused by protein misfolding and aggregation, affecting brain function causing dementia. Amyloid beta (Aβ), peptide deriving from amyloid precursor (APP) cleavage by-and γ-secretases, considered pathological hallmark of AD. Our previous study, together with several lines evidence, identified strict link between APP, Aβ 37/67kDa laminin receptor (LR), finding the possibility to regulate intracellular APP localization maturation...
BRCA1 and BRCA2 are the genes most frequently associated with hereditary breast ovarian cancer (HBOC). They crucial for maintenance of genome stability, particularly in homologous recombination-mediated repair pathway DNA double-strand breaks (HR-DSBR). Widespread BRCA1/2 next-generation sequencing (NGS) screening has revealed numerous variants uncertain significance. Assessing clinical significance these is challenging, regarding management patients. Here, we report functional...
BRCA1 and BRCA2 are the most mutated genes in breast cancer. We analyzed 48 cancer subjects using two methods that differ terms of number investigated strategy used (primers: Panel A - 12 vs probes: B genes). Both panels procedures identified "pathogenic" or "likely pathogenic" variants TP53, ATM, CHEK2 BARD1 besides BRCA2. other putatively pathogenic RNASEL RAD50. Identification than BRCA can be useful patient management. total 121 were distributed within correctly detected by both panels....
Indirect transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been investigated but it is still not completely understood. The present study aimed to compare the persistence and viability lineage B.1 omicron BA.1 subvariant in five daily-use materials evaluate role fomites as a possible source infection. Artificial contamination was performed first set materials, ethylene vinyl acetate (EVA), cardboard, polystyrene, aluminium, plastic. Further surfaces using...
<div>AbstractPurpose:<p>The multi-kinase inhibitor (mKi) regorafenib has demonstrated efficacy in chemorefractory patients with metastatic colorectal cancer (mCRC). However, lack of predictive biomarkers and concerns over significant toxicities hamper the use clinical practice.</p>Experimental Design:<p>Serial liquid biopsies were obtained at baseline monthly until disease progression mCRC treated a phase II trial (PROSPECT-R <i>n</i> = 40; NCT03010722)...
<div>AbstractPurpose:<p>The multi-kinase inhibitor (mKi) regorafenib has demonstrated efficacy in chemorefractory patients with metastatic colorectal cancer (mCRC). However, lack of predictive biomarkers and concerns over significant toxicities hamper the use clinical practice.</p>Experimental Design:<p>Serial liquid biopsies were obtained at baseline monthly until disease progression mCRC treated a phase II trial (PROSPECT-R <i>n</i> = 40; NCT03010722)...
<p>List of Reagents</p>
<p>Supplementary Figure S5. Ex vivo co-cultures</p>
<p>Supplementary Figure S6. MIR652-3p targets PSAT1 and ANGPT1</p>
<p>Supplementary Figure S3. MIR652-3p modulation and cancer phenotype in cell lines PDOs</p>
<p>Supplementary Figure S6. MIR652-3p targets PSAT1 and ANGPT1</p>
<p>Supplementary Figure S3. MIR652-3p modulation and cancer phenotype in cell lines PDOs</p>
<p>Supplementary Figure S5. Ex vivo co-cultures</p>