Jinchao Gu

ORCID: 0009-0008-5982-465X
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About
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Research Areas
  • Pluripotent Stem Cells Research
  • CRISPR and Genetic Engineering
  • Hereditary Neurological Disorders
  • Cancer-related molecular mechanisms research
  • MicroRNA in disease regulation
  • Inflammasome and immune disorders
  • Muscle Physiology and Disorders
  • 3D Printing in Biomedical Research
  • Cellular transport and secretion
  • Endoplasmic Reticulum Stress and Disease
  • Retinal Development and Disorders
  • Traditional Chinese Medicine Studies
  • Oral Health Pathology and Treatment
  • Oral microbiology and periodontitis research
  • Neurogenesis and neuroplasticity mechanisms
  • Lipid metabolism and disorders
  • Traditional Chinese Medicine Analysis
  • RNA Interference and Gene Delivery
  • Circular RNAs in diseases
  • Ion channel regulation and function
  • Salivary Gland Disorders and Functions

Monash University
2023-2025

Guangzhou University of Chinese Medicine
2022-2024

Swinburne University of Technology
2020-2023

Yuxian People's Hospital
2021

Atherosclerosis is a chronic inflammatory disease characterized by the formation of plaque and endothelial dysfunction. Under pro-inflammatory conditions, cells adopt mesenchymal phenotype process called endothelial-to-mesenchymal transition (EndMT) which plays an important role in pathogenesis atherosclerosis. Dan-Shen-Yin (DSY) well-known traditional Chinese medicine used treatment cardiovascular disease. However, molecular mechanism whereby DSY mitigates atherosclerosis remains unknown....

10.3389/fphar.2022.946193 article EN cc-by Frontiers in Pharmacology 2022-08-24

The neuronal progenitor NG108-15 neuroblastoma x glioma cell line proliferates indefinitely in vitro and is capable of directed differentiation into cholinergic neurons. a robust model for investigating function vitro. lineage-specific transcription factor-mediated pluripotent stem lines (PSCs) leads to more rapid, efficient, functional In this study, we tested the hypothesis that factors could also drive fate an immortalised line. We first established stable line, by piggyBac (pBac)...

10.3390/biom15050637 article EN cc-by Biomolecules 2025-04-29

Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction and plaque formation. Under pro-inflammatory conditions, cells can undergo endothelial-to-mesenchymal transition (EndMT), contributing to atherosclerosis development. However, the specific regulatory mechanisms which EndMT contributes remain unclear require further investigation. Dan-Shen-Yin (DSY), traditional Chinese herbal formula, commonly used for cardiovascular diseases, but its molecular...

10.3389/fcvm.2023.1322252 article EN cc-by Frontiers in Cardiovascular Medicine 2024-01-10

Purpose: To investigate the therapeutic effects of minocycline combined with tinidazole in treatment chronic periodontitis (CP). Methods: Seventy-three CP patients treated May 2018–December 2019 at Yuyao People’s Hospital (Yuyao, China) were enrolled this study: 34 alone (control group; CG) and 39 a combination (observation OG). Both groups continuously for four weeks plaque index (PLI), bleeding (BI), periodontal pocket depth (PD), attachment level (PAL) alveolar bone height compared before...

10.25011/cim.v44i3.36477 article EN Clinical and investigative medicine 2021-10-03
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