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A5071021846Summary Recent 3D analyses reported abundant, small beta-cell-rich endocrine objects (EOs) in the human pancreas. Here, we assessed morphological parameters of >262,000 EOs pancreas sections from 220 donors with or without type 1 diabetes (T1D), ranging age and disease duration. We observe many insulin (Ins)+/glucagon (Gluc)-EOs diabetes. Their relative contribution to total area is greatest early life (0-2y) but reduces thereafter. Strikingly, show virtual absence Ins+Gluc- individuals...
10.1101/2025.04.11.648319
preprint
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cc-by
bioRxiv (Cold Spring Harbor Laboratory)
2025-04-17
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