A5084746570- Prenatal Screening and Diagnostics
- Gestational Diabetes Research and Management
- Congenital Heart Disease Studies
- Genomic variations and chromosomal abnormalities
- Pregnancy and preeclampsia studies
- Congenital heart defects research
- Ethics and Legal Issues in Pediatric Healthcare
- Assisted Reproductive Technology and Twin Pregnancy
- Vascular Malformations Diagnosis and Treatment
- RNA Research and Splicing
- Biomedical Text Mining and Ontologies
- Cholesterol and Lipid Metabolism
- Ethics in Clinical Research
- Renal and related cancers
- Ovarian function and disorders
- Vascular Malformations and Hemangiomas
- Advancements in Semiconductor Devices and Circuit Design
- Structural Health Monitoring Techniques
- Advanced Measurement and Detection Methods
- Parallel Computing and Optimization Techniques
- Genetic and Kidney Cyst Diseases
- Digital and Traditional Archives Management
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and biosynthesis
- Tumors and Oncological Cases
Canadian Physiotherapy Association
2024
Saint Louis University
2012-2023
Cardinal Glennon Children’s Medical Center
2021
UCLouvain Saint-Louis Brussels
2017
Washington University in St. Louis
2010-2012
University of Cincinnati
2004
Mosaicism is increasingly recognized as a cause of developmental disorders with the advent next-generation sequencing (NGS). Mosaic mutations PIK3CA have been associated widest spectrum phenotypes overgrowth and vascular malformations. We performed targeted NGS using 2 independent deep-coverage methods that utilize molecular inversion probes amplicon in cohort 241 samples from 181 individuals brain and/or body overgrowth. identified 60 individuals. Several other (n = 12) were separately to...
ABSTRACT Objective To evaluate the efficiency of first‐trimester fetal growth restriction (FGR), low pregnancy‐associated plasma protein A (PAPP‐A), and their combination for predicting small gestational age (SGA) at delivery. Methods Retrospective cohort study women undergoing aneuploidy screening. Fetal crown–rump lengths (CRLs) were 10 to 14 weeks’ gestation converted adjusted Z ‐scores. Low PAPP‐A was defined as levels < 5th percentile GA. Receiver‐operating characteristic curves used...
The purpose of this study was to compare the screening efficiency for Down syndrome using likelihood ratios versus logistic regression coefficients.We conducted a retrospective women at increased risk referred second-trimester genetic sonogram. Likelihood were calculated by multiplying ratio from maternal serum sonographic markers. Logistic coefficients formula derived β generated multivariable model. both methods tested in an independent population patients. McNemar test used predictive...
To examine whether obstetricians think that cardiac surgery is ethical in babies with common aneuploidies and insurance companies should be required to pay for these surgeries.A survey was e-mailed 2897 OB-GYNs, 898 (31%) actively practicing responded the survey. Respondents were asked it offer heart defects diagnosed trisomies 21, 18, 13 Turner syndrome such surgeries cases of trisomy 18 or 13. Chi-square tests utilized compare responses by using an alpha level .05.Most thought offering if...
We evaluated the impact of assisted reproductive technology (ART) on association between first-trimester pregnancy-associated plasma protein A (PAPP-A) and human chorionic gonadotropin (β-hCG) adverse pregnancy outcomes. PAPP-A β-hCG levels were obtained 11 13 (6)/ (7) weeks' gestation converted to multiples median (MoM). MoM < 5th percentile was defined as low or those > 90th high. Adverse outcomes included small-for-gestational-age (SGA) infants, preeclampsia, loss, preterm delivery (PTD)....
The types, interpretation, and use of first- second-trimester aneuploidy screening are often unclear for many women. This impairs appropriate decision making understanding the implications prenatal genetic testing options. purpose this study was to examine utilization Stepwise Sequential in our Midwestern population, demographic factors associated with choice method risk reporting it's potential impact on women's choices. First trimester performed 2,634 women during period. Results were not...
Introduction: Librarians are continually advocating for the expertise they can bring to knowledge synthesis research projects. Professional associations like Canadian Health Libraries Association (CHLA) aim promote librarians and information professionals as partners in health research. This push representation must happen at a policy level order enact change. To that purpose, we explored degree which inclusion of is represented funding by healthcare organizations Canada. Methods: We used...
OBJECTIVES: Structural chromosome aberrations occurring in damage cannot be restored to the original structure.Due breaks occur structural changes.Further, they are connected an anomalous combination.Chromosomal rearrangements spontaneously at low frequency and can caused by damaging agents such as ionizing radiation, some viral infections many chemicals.Changes that disrupt normal balance of functional genes usually end up with abnormal manifestations.METHODS: The child was born 4...
INTRODUCTION: This study was designed to examine the willingness of obstetricians offer CD when fetus has a common aneuploidy and assess regional differences in United States. METHODS: A survey emailed 2,875 OB-GYNs 902 (31%) actively practicing Obstetricians responded. Respondents were categorized into U.S. Census Bureau regions based on their primary state practice with 160 (19%) from Northeast (NE), 263 (29%) Midwest (MW), 267 (32%) South (S), 163 (20%) West (W). We asked “Would you for...
Recent reports suggest that early fetal growth restriction is associated with abnormalities in late pregnancy. Our objective to validate these findings our population by estimating the effectiveness of first-trimester predicting SGA at delivery. We identified pregnancies mothers reliable last menstrual periods and regular cycles seen between 10 14 weeks. excluded multiple gestations, those aneuploidy or structural later pregnancy conceptions from failed contraceptives. Fetal crown–rump...