A5092783742- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Anesthesia and Pain Management
- Plant Toxicity and Pharmacological Properties
- Spinal Hematomas and Complications
- Orthopaedic implants and arthroplasty
Tokai University
2023-2024
Low back pain (LBP) is a pervasive global health concern, primarily associated with intervertebral disc (IVD) degeneration. Although oxidative stress has been shown to contribute IVD degeneration, the underlying mechanisms remain undetermined. This study aimed unravel role of superoxide dismutase 2 (SOD2) in pathogenesis and target limit SOD2 demonstrated dynamic regulation surgically excised human tissues, initial upregulation moderate degeneration downregulation severely degenerated IVDs....
To develop an off-the-shelf therapeutic product for intervertebral disc (IVD) repair using nucleus pulposus cells (NPCs), it is beneficial to mitigate dimethyl sulfoxide (DMSO)-induced cytotoxicity caused by intracellular reactive oxygen species (ROS). Hyaluronic acid (HA) has been shown protect chondrocytes against ROS. Therefore, we examined the potential of HA on mitigating DMSO-induced enhancement NPC therapy. Human cryopreserved in DMSO solutions were thawed, mixed with equal amounts...
Cell transplantation is being actively explored as a regenerative therapy for discogenic back pain. This study the potential of Tie2