A5103543789- Ophthalmology and Eye Disorders
- Facial Rejuvenation and Surgery Techniques
- Facial Trauma and Fracture Management
- Ocular Disorders and Treatments
- Soft tissue tumor case studies
- Botulinum Toxin and Related Neurological Disorders
- Nasolacrimal Duct Obstruction Treatments
- Ocular Surface and Contact Lens
- Quantum optics and atomic interactions
- Traumatic Ocular and Foreign Body Injuries
- Head and Neck Surgical Oncology
- Nasal Surgery and Airway Studies
- IgG4-Related and Inflammatory Diseases
- Parathyroid Disorders and Treatments
- Quantum Dots Synthesis And Properties
- Sinusitis and nasal conditions
- Ocular Oncology and Treatments
- Craniofacial Disorders and Treatments
- Bone Tumor Diagnosis and Treatments
- Genetic Syndromes and Imprinting
- Glaucoma and retinal disorders
- Quantum Information and Cryptography
- Vascular Tumors and Angiosarcomas
- Facial Nerve Paralysis Treatment and Research
- Mechanical and Optical Resonators
University of Louisville
2015-2025
Visual Sciences (United States)
2019
Orbital Research (United States)
2014-2017
University of Louisville Hospital
2015
National Institute of Standards and Technology
2014
Florida A&M University - Florida State University College of Engineering
2010
Rochester Institute of Technology
2008
The University of Texas Southwestern Medical Center
2005
Southwestern Medical Center
2005
Vanderbilt University
2005
A defect in Klotho gene expression mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression extends life span. protein functions as a circulating hormone binds to cell-surface receptor and represses intracellular signals insulin insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending Alleviation aging-like phenotypes Klotho-deficient was observed by perturbing IGF1 signaling, suggesting Klotho-mediated inhibition...
klotho is an aging suppressor gene and extends life span when overexpressed in mice. Klotho protein was recently demonstrated to function as a hormone that inhibits insulin/insulin-like growth factor-1 (IGF-1) signaling. Here we show increases resistance oxidative stress at the cellular organismal level mammals. activates FoxO forkhead transcription factors are negatively regulated by insulin/IGF-1 signaling, thereby inducing expression of manganese superoxide dismutase. This turn...
Tensile strain compensation (SC) layers were introduced into GaAs p-i-n solar cells grown with a five-stack of InAs quantum dots (QDs) within the i-region. The effects stacked investigated using high resolution x-ray diffraction (HRXRD). Analysis HRXRD data shows that average lattice is minimized for optimal SC thickness. One sun air mass zero illuminated current-voltage curves show results in improved conversion efficiency and reduced dark current when compared to uncompensated devices....
Introduction: To report a case of Extranodal NK/T-cell lymphoma the orbit mimicking orbital cellulitis.Case Description: A 52-year-old healthy male presented to our institution after 3 months treatment for sinusitis with antibiotics and steroids. The patient was transferred due presence an "orbital abscess" on CT signs that not responding antibiotics. Clinical examination significant decreased vision in affected 20/50, trace RAPD OS, elevated IOP 30 proptosis grossly motility diplopia,...
To compare the radiological differences in retro-orbicularis oculi fat (ROOF) and suborbiculars (SOOF) among patients with thyroid-associated orbitopathy (TAO) normal subjects using computed tomography (CT).A retrospective analysis of orbital CTs was performed 39 consecutive patients, who were imaged between October 2005 June 2009. Bilateral 16 a final report significant for thyroid 23 evaluated. All consisted 0.75 mm thick axial slices 1.5 coronal reconstructions. Using soft tissue windows,...
To describe a technique to correct lower eyelid malposition and lagophthalmos due facial nerve palsy.Chart review was performed identified 13 patients with palsy, who presented paralytic were treated recession extirpation of the retractors between September 2012 March 2014 by 1 surgeon (HBL).A total 12 eyelids in 11 met inclusion criteria. Mean preoperative MRD2 10 mm (range, 9.0-12.0 mm) mean postoperative 7 5.0-9.0 mm). The improved an average 3.0 each patient 2.0-4.0 Patients had 6.9...
A 13-month-old boy was presented with new onset proptosis of the right eye. CT scan and MRI showed an enhancing mass in superior orbit local bone remodeling erosion. craniotomy performed for biopsy sub-total resection. Histopathology immunohistochemistry confirmed lesion to be nodular fasciitis. Nodular fasciitis lesions are classically found anterior ocular adnexa, especially pediatric patients. This is first reported case arising posterior a child younger than 16.
We report here a newborn male infant with striking features consistent severe Pfeiffer syndrome type II, including cloverleaf skull deformity pansynostosis, extreme proptosis, upper extremity contractures, broad big toes and thumbs varus deviation genetic mutation in the FGFR2 gene. The authors review ophthalmic complications discuss unique surgical strategies used for obtaining adequate corneal coverage these patients.Ophthalmic considerations Type 2 Syndrome include vision loss secondary...
Porous polyethylene is commonly used in the orbit for fracture repair and anophthalmic reconstruction; it reportedly has a good safety profile integrates well into host tissue. Foreign body reaction to porous been reported facial tissue, but our knowledge, not orbit. The authors report 2 cases of foreign inflammatory giant cell patients who underwent orbital repairs with implants.
PurposeTo report our experience with protractor myectomy in patients benign essential blepharospasm who did not respond to serial botulinum toxin injection, and describe intra- postoperative techniques that limited skin contracture while also providing excellent functional cosmetic results.
 MethodsThe medical records of isolated, benign, underwent from 2005 2008 by a single surgeon were reviewed retrospectively. The technique entailed operating on eyelid during each procedure, using...
An 8-year-old boy had painless swelling of the right eyelid that reduced during downward gaze (shown in a video). A mass was palpated within eyelid. MRI showed along anteroinferior portion globe.
Subperiosteal extension of a subgaleal hematoma (SGH) to the orbit is reported, but rare complication trauma. This report details 13-year-old African-American male who originally presented emergency department after trauma with headache and was found on CT imaging have contained hemorrhage. He 2 days later increased pain proptosis left eye findings decreased visual acuity, elevated intraocular pressure, proptosis, complete external ophthalmoplegia. Repeat revealed enlargement SGH...
Sellar arachnoid cysts (SACs) are rare lesions and incidentally found on brain imaging. The pathophysiology is poorly understood. Some authors suggested that SACs develop as a herniation of membrane through the diaphragma sellae followed by cyst formation. Furthermore, Meyer et al. postulated formed splitting layers. Symptomatic present with headache, visual field deficit, or pituitary dysfunction. data limited indications timing for intervention. We case symptomatic SAC was fenestrated...
Since ptosis is an early feature of chronic progressive external ophthalmoplegia (CPEO), patients are commonly misdiagnosed with other causes ptosis. This study aims to report the type and frequency misdiagnosis time lag diagnosis palpebral fissure transfer (PFT) procedure in CPEO.
Abstract Purpose: To compare meibomian gland (MG) loss and MG dysfunction (MGD) in patients with mild versus moderate-severe thyroid eye disease (TED). Methods: Consecutive TED no other causes of dry underwent meibography meiboscore each eyelid were graded as 0 (no loss), 1 (<33% 2 (33%–66% 3 (>66% a total score 0–6. expression (0–3), margin signs MGD, lipid layer thickness (LLT), ocular surface index (OSDI), tear secretion, noninvasive break-up time (NITBUT), meniscus height (TMH)...