A5013069348- Veterinary medicine and infectious diseases
- Viral Infections and Vectors
- Leptospirosis research and findings
- Helicobacter pylori-related gastroenterology studies
- Antibiotics Pharmacokinetics and Efficacy
- Animal health and immunology
University of Tennessee at Knoxville
2021-2024
Knoxville College
2021-2022
Background: Ruminant species are at risk of developing abomasal ulceration, but there is a lack pharmacokinetic data for anti-ulcer therapies, such as the proton pump inhibitor pantoprazole, in goats. Objective: The primary study objective was to estimate plasma parameters pantoprazole adult goats after intravenous administration. A secondary describe metabolite, sulfone, Methods: Pantoprazole administered intravenously six dose 1 mg/kg. Plasma samples were collected over 36h and analyzed...
Background Stressed and hospitalized goats are at risk of developing abomasal (gastric) ulceration, but there is a paucity pharmacokinetic studies for proton pump inhibiting drugs, such as, esomeprazole in goats. Objectives The objectives this study were to estimate plasma parameters adult after intravenous (IV) subcutaneous (SQ) administration. A secondary objective was describe the kinetics metabolite sulfone IV SC administration Materials methods Esomeprazole administered 5 crossover...
Abstract Leptospirosis is the most widespread zoonosis and a life-threating disease of humans animals. Licensed killed whole-cell vaccines are available for animals; however, they do not offer heterologous protection, induce long-term or prevent renal colonization. In this study, we characterized an immunogenic Leptospira methyl-accepting chemotaxis protein (MCP) identified through reverse vaccinology approach, predicted its structure, tested protective efficacy recombinant MCP fragment in...
Leptospirosis is the most widespread zoonosis and a life-threatening disease in humans animals. Licensed killed whole-cell vaccines are available for animals; however, they do not offer heterologous protection, induce long-term or prevent renal colonization. In this study, we characterized an immunogenic Leptospira methyl-accepting chemotaxis protein (MCP) identified through reverse vaccinology approach, predicted its structure, tested protective efficacy of recombinant MCP fragment C3H/HeJ...