A5027828400- Neuroendocrine Tumor Research Advances
- Pituitary Gland Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Adrenal and Paraganglionic Tumors
- Effects of Radiation Exposure
- Hormonal Regulation and Hypertension
- Pancreatic function and diabetes
- Pluripotent Stem Cells Research
- DNA Repair Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Neuroblastoma Research and Treatments
Cornell University
2025
Weill Cornell Medicine
2025
Boston University
2017
Dana-Farber Cancer Institute
2016
Abstract Radiotherapy is not currently informed by the genetic composition of an individual patient’s tumour. To identify features regulating survival after DNA damage, here we conduct large-scale profiling cellular exposure to radiation in a diverse collection 533 genetically annotated human tumour cell lines. We show that sensitivity characterized significant variation across and within lineages. combine results from our platform with genomic parameters predict sensitivity. somatic copy...
Tissue-specific endothelial cells (ECs) are critical for the homeostasis of pancreatic islets and most other tissues. In vitro recapitulation islet biology therapeutic transplantation both require adequate vascularization, which remains a challenge. Using human reprogrammed vascular ECs (R-VECs), were functionally vascularized in vitro, demonstrating responsive, dynamic glucose-stimulated insulin secretion Ca 2+ influx. Subcutaneous with R-VECs reversed hyperglycemia diabetic mice, high...
Abstract Adhesion to extracellular matrix (ECM) is crucially important for survival of normal epithelial cells as detachment from ECM triggers specific apoptosis known anoikis. As tumor lose the requirement anchorage ECM, they rely on cell–cell adhesion ‘multicellular aggregation’ survival. Multicellular aggregation also significantly determines sensitivity cytotoxic effects chemotherapeutics. In this report, we demonstrate that expression immunoglobulin containing and proline-rich...