A5104067464- Diabetes Management and Research
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Diet and metabolism studies
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Pharmacology and Obesity Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Genetic Associations and Epidemiology
- Sarcoma Diagnosis and Treatment
- Synthesis and Biological Evaluation
- Social and Cultural Dynamics
- Legal and Constitutional Studies
- Philosophy and Literary Analysis
- Art Education and Development
- Physical Activity and Health
- Cardiovascular Function and Risk Factors
- Meningioma and schwannoma management
- Diverse Education Studies and Reforms
- Neurological and metabolic disorders
- Legal Systems and Judicial Processes
- Marine Toxins and Detection Methods
- Educational Environments and Student Outcomes
- Lysosomal Storage Disorders Research
Mitchell Institute
2025
Texas A&M University
2025
Boston Children's Hospital
2020-2022
Dana-Farber Brigham Cancer Center
2020-2022
Brigham and Women's Hospital
2020-2022
Dana-Farber Cancer Institute
2020-2022
Harvard University
2020-2021
St. John's University
2012
University of New Mexico
1993-2008
New Mexico Highlands University
1996
In patients with insulin-dependent diabetes mellitus (IDDM) whose treatment results in nearly normal mean plasma glucose concentrations, an unawareness of hypoglycemia can develop, and such are at increased risk for seizures coma. We tested the hypothesis that during hypoglycemia, these would have uptake brain consequently no sympathoadrenal activation begin, resulting hypoglycemia.
BACKGROUND: Aggressive management of type 2 diabetes is necessary to achieve glycemic and nonglycemic treatment goals. Attainment oftreatment goals associated with a decreased risk diabetes-related complications, costs, health care utilization. OBJECTIVE: To review the advantages disadvantages different glucose-lowering agents, an emphasis on role thiazolidinediones(TZDs). SUMMARY: Diabetes has become increasingly prevalent, particularly among younger age groups in United States, accounting...
More than 1 million people in the US identify as transgender; however, few studies have examined experiences and outcomes of transgender patients with cancer.To examine clinical characteristics, experiences, cancer.This retrospective case series assessed at least cancer diagnosis who were evaluated Dana-Farber Cancer Institute or Brigham Women's Hospital Boston, Massachusetts, between January 1, 2005, December 31, 2019.Demographic, clinical, treatment characteristics for all documentation by...
We tested the hypotheses that nonselective beta-adrenergic blockade does not cause absolute hypoglycemia unawareness but shifts glycemic thresholds for symptoms to lower plasma glucose concentrations and neither neuroglycopenic nor cognitive impairments during are altered by blockade. To do so, we applied euglycemic stepped hypoglycemic clamp techniques patients with moderately controlled insulin-dependent diabetes mellitus (IDDM) in absence (n = 8) presence 9) of antagonist propranolol....
Objective— To test the clinical use of octreotide in treatment sulfonylurea-induced hypoglycemia. Research Design and Methods— A case is reported hypoglycemic coma a nondiabetic subject, which was complicated by relapse hypoglycemia after resuscitation with intravenous dextrose. Subcutaneous octreotide, 50 μg 12 hourly, suppressed stimulated endogenous insulin secretion, thereby preventing further recurrence Results— No adverse effects were observed. Conclusions— These results suggest...
During hypoglycemia, substrates other than glucose have been suggested to serve as alternate neural fuels. We evaluated brain uptake of endogenously produced lactate, alanine, and leucine at euglycemia during insulin-induced hypoglycemia in 17 normal subjects. Cross-brain arteriovenous differences for plasma glucose, leucine, oxygen content were quantitated. Cerebral blood flow (CBF) was measured by Fick methodology using N(2)O the dilution indicator gas. Substrate product CBF concentration...
OBJECTIVE To see if glucocorticoid deficiency might explain increased insulin sensitivity causing severe brittle diabetes in two type 1 diabetic patients. CASES We describe patients who developed characterized by recurrent hypoglycemia on small daily doses with hyperglycemia further dose reduction. In both patients, requirements had fallen markedly. RESULTS Both were found to have deficiency. one patient, this was a result of hypopituitarism, which aggravated growth hormone the other primary...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic intermediates potentially useful for the synthesis of tetrodotoxin and derivatives. 8. A series highly functionalized pyrimidinonesJohn F. W. Keana, Patrick J. Boyle, Mark Erion, Ross Hartling, James R. Husman, Jack E. Richman, Richard B. Roman, Robert M. WahCite this: Org. Chem. 1983, 48, 21, 3621–3626Publication Date (Print):October 1, 1983Publication History Published online1 May 2002Published inissue 1 October...
Pulmonary metastases are common in many pediatric solid tumors; however, little is known about safety and efficacy of lung stereotactic body radiation therapy (SBRT) for patients. We conducted a phase I/II study to investigate the minimum effective dose level SBRT with an acceptable profile patients.Patients sarcoma metastatic pulmonary lesions ≤3 cm diameter ≤21 years age were enrolled. Dose levels 1, 2, 3 24, 30, 36 Gy fractions, respectively. Enrolled patients from primary renal tumors...
While most resection specimens from patients with neoadjuvantly treated esophageal squamous cell carcinoma show therapy-related changes in the form of inflammation and fibrosis, others harbor a florid foreign body-type giant response to keratin debris. The purpose our study was perform detailed clinicopathologic analysis these histologic types treatment responses correlate findings patient outcome. Clinical pathologic parameters 110 esophagogastrectomies were recorded analyzed. Two main...
MR-linacs (MRLs) have enabled the use of stereotactic magnetic resonance (MR) guided online adaptive radiotherapy (SMART) across many cancers. As data emerges to support SMART, uncertainty remains regarding optimal technical parameters, such as patient positioning, immobilization, image quality, and contouring protocols. Prior clinical implementation we conducted a prospective study in healthy volunteers (HVs) determine parameters develop practice multidisciplinary SMART workflow.
Abstract Central nervous system (CNS) metastases are rare, but devastating complications of pediatric solid tumors. Radiotherapy alone or postresection serves as an important treatment; however, data on the use whole‐brain radiotherapy (WBRT) versus focal radiotherapy, including stereotactic radiosurgery for these indications limited. We report a single institution experience 26 patients treated with tumor CNS without leptomeningeal disease. Focal ( n = 10) was well tolerated and survival...