A5086818068- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Cavitation Phenomena
- Rheology and Fluid Dynamics Studies
- Ultrasound Imaging and Elastography
- Fluid Dynamics Simulations and Interactions
- Electrospun Nanofibers in Biomedical Applications
- Force Microscopy Techniques and Applications
- Fluid Dynamics and Heat Transfer
- Flow Measurement and Analysis
- Model Reduction and Neural Networks
- Fluid Dynamics and Mixing
- Combustion and flame dynamics
- Structural Health Monitoring Techniques
- Bone Tissue Engineering Materials
- Lattice Boltzmann Simulation Studies
- Elasticity and Material Modeling
- Particle Dynamics in Fluid Flows
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cardiovascular and Diving-Related Complications
- Blood properties and coagulation
- Probabilistic and Robust Engineering Design
- Aerosol Filtration and Electrostatic Precipitation
- Tendon Structure and Treatment
University of Michigan
2022-2025
Phase-shift droplets are a highly adaptable platform for biomedical applications of ultrasound. The spatiotemporal response phase-shift to focused ultrasound above certain pressure threshold, termed acoustic droplet vaporization (ADV), is influenced by intrinsic features (e.g., bulk boiling point) and extrinsic factors driving frequency surrounding media). A deep understanding ADV dynamics critical ensure the robustness repeatability an ADV-assisted application. Here, we integrated...
Acoustic droplet vaporization (ADV) offers a dynamic approach for generating bubbles on demand, presenting new possibilities in biomedical applications. Although ADV has been investigated various applications, its potential tissue characterization remains unexplored. Here, we the effects of surrounding media radial dynamics and acoustic emissions using theoretical experimental methodologies. For studies, bubble were combined with Kelvin-Voigt material constitutive model, accounting...
Shell-stabilized, phase-shift droplets of perfluorocarbon have shown promising potential in diagnostic and therapeutic ultrasound applications. While the role shell composition has been well-studied for conventional gas-filled microbubbles, its influence on bubbles generated via acoustic droplet vaporization (ADV) remains understudied. This study investigates effect composition─lipid, protein, polymer─on stability, ADV dynamics, growth behavior, release kinetics, response perfluorohexane...
Contemporary material characterization techniques that leverage deformation fields and the weak form of equilibrium equations face challenges in numerical solution procedure inverse problem. As models descriptions differ, so too must approaches for identifying parameters their corresponding mechanisms. The widely used Ogden model can be comprised a chosen number terms same mathematical form, which presents parsimonious representation, interpretability stability. Robust system identification...
Phase-shift droplets provide a flexible and dynamic platform for therapeutic diagnostic applications of ultrasound. The spatiotemporal response phase-shift to focused ultrasound, via the mechanism termed acoustic droplet vaporization (ADV), can generate range bioeffects. Although ADV has been used widely in theranostic applications, ADV-induced bioeffects are understudied. Here, we integrated ultra-high-speed microscopy, confocal ultrasound real-time visualization mechanics sonoporation...
An understanding of inertial cavitation is crucial for biological and engineering applications such as non-invasive tissue surgeries the mitigation potential blast injuries. However, predictive modeling in tissues hindered by difficulties characterizing fluids soft materials at high strain rates, computational cost calibrating biologically-relevant viscoelastic models. By incorporating a reduced-order model microcavitation rheometry (IMR) experimental technique, we present an efficient...
Acoustic droplet vaporization (ADV) offers a dynamic approach for generating bubbles on demand, presenting new possibilities in biomedical applications. Although ADV has been investigated various applications, its potential tissue characterization remains unexplored. Here, we the effects of surrounding media radial dynamics and acoustic emissions using theoretical experimental methodologies. For studies, bubble were combined with Kelvin-Voight material constitutive model, accounting...
Ultrasound-induced vaporization of phase-shift droplets (PSDs) into microbubbles, termed acoustic droplet (ADV), has expanded biomedical applications. Here, we explored the potential ADV as a high-resolution, on-demand microrheometer using theoretical and experimental methodologies. This approach could be used to characterize tissue elasticity at spatial resolutions unrealizable with conventional in situ techniques, thus assisting identification underlying pathologies. For studies, bubble...
Shell-stabilized, phase-shift droplets of a perfluorocarbon liquid have been investigated for wide range applications. The shell plays key role in maintaining droplet stability and impacting the acoustic responses generated bubbles via vaporization (ADV). While behavior under ultrasound exposure is well-studied with contrast microbubbles, it not fully explored during post ADV. By integrating ultra-high-speed microscopy time-lapse confocal imaging, we radial dynamics ADV growth rate post-ADV...
Perfluorocarbon (PFC) droplets represent a novel class of phase-shift contrast agent with promise in applications biomedical and bioengineering fields. PFC undergo fast liquid-gas transition upon exposure to acoustic or optical triggering, offering potential adaptable versatile tool as diagnostics imaging localized drug delivery vehicles therapeutics systems. In this paper, we utilize advanced techniques investigate ultra-high-speed inertial dynamics rectified quasi-static (low-speed)...
Acoustic droplet vaporization (ADV) enables phase-shift droplets to respond focused ultrasound in a spatiotemporal manner, offering versatile platform for theranostic applications. To better understand the ADV-inducedmechanics and resulting bioeffects real-time, we integrated ultra-high-speed microscopy (up 10 million frames per second), time-lapse confocal microscopy, ultrasound. Three monodispersed droplets—containing perfluoropentane (PFP), perfluorohexane (PFH), or perfluorooctane...
Contemporary material characterisation techniques that leverage deformation fields and the weak form of equilibrium equations face challenges in numerical solution procedure inverse problem. As models descriptions differ, so too must approaches for identifying parameters their corresponding mechanisms. The widely-used Ogden model can be comprised a chosen number terms same mathematical form, which presents parsimonious representation, interpretability, stability. Robust system identification...