A5014058986- Analytical Chemistry and Chromatography
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
Nawi Graz
2021
University of Graz
2021
Research Center Pharmaceutical Engineering (Austria)
2021
The development of a continuous-flow sequence for the synthesis an important drug candidate precursor is reported. Abediterol β2-adrenoceptor agonist that has undergone phase IIa clinical trials treatment respiratory disease. A flow developed preparation lipophilic amine tail portion abediterol. comprises phase-transfer-catalyzed liquid/liquid O-alkylation, rhodium-catalyzed hydroformylation, and ruthenium-catalyzed reductive amination. reactions were optimized separately within environments...