A5064829489- Infectious Encephalopathies and Encephalitis
- Bacterial Infections and Vaccines
- Epilepsy research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Head and Neck Surgical Oncology
- Multiple Sclerosis Research Studies
- Sleep and related disorders
- Traumatic Brain Injury Research
- Metabolism and Genetic Disorders
- Cell death mechanisms and regulation
- Intraoperative Neuromonitoring and Anesthetic Effects
- Pesticide Exposure and Toxicity
- Cannabis and Cannabinoid Research
- Neonatal and fetal brain pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Muscle activation and electromyography studies
- Sleep and Wakefulness Research
- Neuropeptides and Animal Physiology
- Influenza Virus Research Studies
- Heart Rate Variability and Autonomic Control
- Cerebral Palsy and Movement Disorders
- Long-Term Effects of COVID-19
- Airway Management and Intubation Techniques
Medical College of Wisconsin
2023-2025
Children's Hospital of Wisconsin
2025
Northwestern University
2023-2024
Mayo Clinic
2023
College of Medicine & JNM Hospital
2022
McLean Hospital
2021-2022
Harvard University
2021-2022
Massachusetts General Hospital
2007
Cell death after traumatic brain injury (TBI) evolves over days to weeks. Despite advances in understanding biochemical mechanisms that contribute posttraumatic cell death, the time course of injury, and removal remains incompletely characterized experimental TBI models. In a mouse controlled cortical impact (CCI) model, plasmalemma permeability propidium iodide (PI) was an early persistent feature cellular cortex hippocampus. hippocampal regions known be vulnerable number PI + cells peaked...
Abstract Objective Therapeutic strategies for patients with febrile infection‐related epilepsy syndrome (FIRES) are limited, ad hoc, and frequently ineffective. Based on evidence that inflammation drives pathogenesis in FIRES, we used ex vivo stimulation of peripheral blood mononuclear cells (PBMCs) to characterize the monocytic response profile before after therapy a child successfully treated dexamethasone delivered intrathecally six times between hospital Day 23 40 at 0.25 mg/kg/dose....
Background: An attenuated heart rate response to exercise, termed chronotropic incompetence, has been reported in Parkinson’s disease (PD). Chronotropic incompetence may be a marker of autonomic dysfunction and cause exercise intolerance early stages PD. Objective: To investigate the relationship between orthostatic blood pressure change (supine – standing), performance (maximal oxygen consumption, VO2peak) individuals with PD within 5 years diagnosis not on dopaminergic medications....
Parkinson’s disease (PD), a heterogeneous with no disease-modifying treatments available, is the fastest growing neurological worldwide. Currently, physical exercise most promising treatment to slow progression, evidence suggesting it neuroprotective in animal models. The onset, and symptom severity of PD are associated low grade, chronic inflammation which can be quantified by measuring inflammatory biomarkers. In this perspective, we argue that C-reactive protein (CRP) should used as...
Febrile infection–related epilepsy syndrome (FIRES) is characterized by explosive onset refractory status epilepticus (RSE) in healthy individuals that to antiseizure medication (ASM), continuous anesthetic infusions (CIs), and immunomodulators. Recently, a case series of patients receiving intrathecal dexamethasone (IT-DEX) was reported with improved RSE control.
Cessation of cannabinoid use in humans often leads to a withdrawal state that includes sleep disruption. Despite important health implications, little is known about how abstention affects architecture, part because spontaneous difficult model animals. In concurrent work we report repeated administration the high-efficacy 1 (CB1) receptor agonist AM2389 mice for 5 days led heightened locomotor activity and paw tremor following treatment discontinuation, potentially indicative withdrawal....