A5055137497- Ion channel regulation and function
- Human Motion and Animation
- Genetic Neurodegenerative Diseases
- Genomics, phytochemicals, and oxidative stress
- Cardiac Arrhythmias and Treatments
- Gaze Tracking and Assistive Technology
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Face recognition and analysis
- Cardiac electrophysiology and arrhythmias
- Fungal and yeast genetics research
- Virtual Reality Applications and Impacts
- Augmented Reality Applications
- Muscle activation and electromyography studies
- Photoreceptor and optogenetics research
German Research Centre for Artificial Intelligence
2023
University of Calgary
2001-2014
Libin Cardiovascular Institute of Alberta
2014
New York State Department of Health
2001
Wadsworth Center
2001
University at Albany, State University of New York
2001
Ca2+ is a key intermediary in variety of signalling pathways and undergoes dynamic changes its cytoplasmic concentration due to release from stores within the endoplasmic reticulum (ER) influx extracellular environment. In addition regulating signals, these responses also affect ER mitochondria. Single fluorescent protein-based indicators, such as GCaMP series based on GFP, are powerful tools for imaging associated with intracellular pathways. Most GCaMP-type indicators have dissociation...
Different forms of ventricular arrhythmias have been linked to mutations in the cardiac ryanodine receptor (RyR)2, but molecular basis for this phenotypic heterogeneity is unknown. We recently demonstrated that an enhanced sensitivity luminal Ca(2+) and increased propensity spontaneous release or store-overload-induced (SOICR) are common defects RyR2 associated with catecholaminergic polymorphic bidirectional tachycardia. Here, we investigated properties a unique mutation idiopathic...
Recombinant type 3 ryanodine receptor (RyR3) has been purified in quantities sufficient for structural characterization by cryoelectron microscopy and three-dimensional (3D) reconstruction. Two cDNAs were prepared expressed HEK293 cells, one encoding the wild-type RyR3 other containing glutathione S-transferase (GST) fused to its amino terminus (GST-RyR3). was from detergent-solubilized transfected cells affinity chromatography using 12.6-kDa FK506-binding protein form of a GST fusion as...
With the advancement of generative artificial intelligence, previous studies have achieved task generating aesthetic images from hand-drawn sketches, fulfilling public's needs for drawing. However, these methods are limited to static and lack ability control video animation generation using sketches. To address this gap, we propose VidSketch, first method capable high-quality animations directly any number sketches simple text prompts, bridging divide between ordinary users professional...
With the rapid development of AIGC technology, significant progress has been made in diffusion model-based technologies for text-to-image (T2I) and text-to-video (T2V). In recent years, a few studies have introduced strategy Direct Preference Optimization (DPO) into T2I tasks, significantly enhancing human preferences generated images. However, existing T2V generation methods lack well-formed pipeline with exact loss function to guide alignment videos using DPO strategies. Additionally,...
For machines to effectively assist humans in challenging visual search tasks, they must differentiate whether a human is simply glancing into scene (navigational intent) or searching for target object (informational intent). Previous research proposed combining electroencephalography (EEG) and eye-tracking measurements recognize such intents implicitly, i.e., without explicit user input. However, the applicability of these approaches real-world scenarios suffers from two key limitations....