A5103219168- Pharmacological Effects and Toxicity Studies
- Renal function and acid-base balance
- Infective Endocarditis Diagnosis and Management
- Sepsis Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Bacterial Infections and Vaccines
- Respiratory Support and Mechanisms
- Parathyroid Disorders and Treatments
- Cardiac Arrest and Resuscitation
- Wound Healing and Treatments
- Immunodeficiency and Autoimmune Disorders
- Surgical site infection prevention
- Histone Deacetylase Inhibitors Research
- Chemotherapy-induced organ toxicity mitigation
- Growth Hormone and Insulin-like Growth Factors
- Streptococcal Infections and Treatments
- Pharmacogenetics and Drug Metabolism
- Metabolism and Genetic Disorders
- Diabetic Foot Ulcer Assessment and Management
- Renal Transplantation Outcomes and Treatments
- Pediatric Urology and Nephrology Studies
- Genetic Syndromes and Imprinting
- Diet and metabolism studies
Inner Mongolia People's Hospital
2024
Sun Yat-sen University
2012-2018
The First Affiliated Hospital, Sun Yat-sen University
2012-2018
University of Pittsburgh
2015
Guangdong Pharmaceutical University
2015
University of Pittsburgh Medical Center
2013
Background: Serum anion gap (AG) has been proven to be associated with prognosis in critically ill patients. However, few studies have investigated the association between AG and all-cause mortality patients chronic obstructive pulmonary disease (COPD). Objective: We hypothesized that initial level would predict risk COPD. Methods: This retrospective cohort study was based on Medical Information Mart for Intensive Care (MIMIC) IV database. extracted demographics, vital signs, laboratory...
Weight gain is the most frequent adverse effect of valproic acid (VPA) treatment, resulting in poor compliance and many endocrine disturbances. Similarities weight change monozygotic twins receiving VPA strongly suggests that genetic factors are involved this effect. However, few studies have been conducted to identify relevant polymorphisms. Additionally, causal relationship between concentration has controversial. Thus, we investigated effects single nucleotide polymorphisms (SNPs) several...
Tacrolimus is a widely used immunosuppressive drug with marked pharmacokinetic variability partly due to CYP3A5 polymorphism. Our study aimed investigate the dynamic effects of genotypes on dose requirement and trough concentration (C0 ) tacrolimus in renal transplant recipients.A total 194 Chinese recipients received oral twice daily. Whole-blood C0 were measured 3rd day, 7th 14th 1st month, month 6th post-transplantation. determined categorized as expressers (CYP3A5*1 allele carriers)...
What is known and objective Jintrolong® a pegylated recombinant human growth hormone (rhGH) (PEG-rhGH) developed for weekly subcutaneous (sc) injection. The current tolerability trial pharmacokinetics (PK) evaluated the safety, PK of single-dose injection in healthy adult subjects. Methods Both trials were single-centre, randomized, open-label studies. In trial, 34 subjects randomized to receive sc (0.01, 0.06, 0.2, 0.5 or 0.8 mg/kg) placebo. study, 30 male evenly into 3 groups (0.1, 0.2 0.4...
A rapid, simple, and reproducible high-performance liquid chromatographic method (HPLC) was developed validated for the determination of mizoribine in human plasma using cytarabine as internal standard (IS). The samples were precipitated with 6% perchloric acid. supernatant separated on a reversed phase C<sub>18</sub> column mobile 10 mM KH<sub>2</sub>PO<sub>4</sub> buffer solution (pH 6.3) containing acid isocratic elution (at flow rate 1.5 mL/min), detected an ultraviolet detector at 280...
A randomized, 2-way crossover study was conducted in healthy Chinese male volunteers to evaluate the bioequivalence of a new generic formulation entecavir (CAS 142217-69-4) tablets (test) and available branded (reference) meet requirements for marketing test product China. Test reference were administered as single dose on 2 treatment days separated by 2-week washout period. Blood samples collected period 24 h following drug administration. Plasma concentration determined liquid...
Purpose: Acute myocardial infarction can be treated with percutaneous coronary intervention. Adequate microvascular perfusion is often not restored due to obstruction (MVO), partly caused by microthrombi. This negatively influences clinical outcomes. We tested the hypothesis that ultrasound (US) mediated microbubble (MB) destruction achieve clot lysis in our vitro MVO model. Methods: The model comprised of a phantom vessel containing an intraluminal mesh 40 μm pores simulate cross section...